ID E9AF75_LEIMA Unreviewed; 396 AA.
AC E9AF75;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|SMART:SM00184};
GN ORFNames=LMJF_35_2520 {ECO:0000313|EMBL:CBZ12879.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12879.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12879.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12879.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796431; CBZ12879.1; -; Genomic_DNA.
DR RefSeq; XP_003722645.1; XM_003722597.1.
DR AlphaFoldDB; E9AF75; -.
DR STRING; 5664.E9AF75; -.
DR EnsemblProtists; CBZ12879; CBZ12879; LMJF_35_2520.
DR GeneID; 12982546; -.
DR KEGG; lma:LMJF_35_2520; -.
DR VEuPathDB; TriTrypDB:LmjF.35.2520; -.
DR VEuPathDB; TriTrypDB:LMJFC_350033400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_350031900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_350031400; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_697293_0_0_1; -.
DR InParanoid; E9AF75; -.
DR OMA; FERYTEM; -.
DR Proteomes; UP000000542; Chromosome 35.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR042862; RNF32.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14991; RING FINGER PROTEIN 32; 1.
DR PANTHER; PTHR14991:SF0; RING FINGER PROTEIN 32; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 4..55
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
FT DOMAIN 327..387
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
SQ SEQUENCE 396 AA; 42521 MW; 3FABC0102EEDAB79 CRC64;
MSYSTNCDEG QVILSCSHVF HARCFRSFER YVRAQQRADA LRIGEVSAPL ACPVCRTQSY
YKRIFYEGKA VAQRAAIVKV QAAVRGLLAR RAYIKIKLQN NPEFRTRYVQ ERLARLSAAW
QTFCAEQEQR RAGLQTALTV QQEMARAAFL SEEAWAEIWR KAVHGPSTSS EPGSSAAPST
AGASVQCPIC LELIHCSQCP GTGAAASHAG GVRRLTGKDA VAAMWAAYEA RKVAKRLPSV
EPKAARASAG ALVRSAVKGA AQRKTGNSLT PMPGAVASVR DGKVASSRAP EHRAGRQKGF
AQPTAAAPWP EHANAFAALS SAPGVDAVGA HEAAVVLPQS GILLSCGHCF HAACIDCYER
FHERRCLDMV EQDGGAVVAF PSRCPVCRSG YAKHPM
//
