ID E9AFA0_LEIMA Unreviewed; 620 AA.
AC E9AFA0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=G domain-containing protein {ECO:0000259|Pfam:PF01926};
GN ORFNames=LMJF_35_2760 {ECO:0000313|EMBL:CBZ12904.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12904.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12904.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12904.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796431; CBZ12904.1; -; Genomic_DNA.
DR RefSeq; XP_003722670.1; XM_003722622.1.
DR AlphaFoldDB; E9AFA0; -.
DR STRING; 5664.E9AFA0; -.
DR EnsemblProtists; CBZ12904; CBZ12904; LMJF_35_2760.
DR GeneID; 12982571; -.
DR KEGG; lma:LMJF_35_2760; -.
DR VEuPathDB; TriTrypDB:LmjF.35.2760; -.
DR VEuPathDB; TriTrypDB:LMJFC_350036000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_350034600; -.
DR VEuPathDB; TriTrypDB:LMJSD75_350033900; -.
DR eggNOG; ENOG502QTV1; Eukaryota.
DR HOGENOM; CLU_431847_0_0_1; -.
DR InParanoid; E9AFA0; -.
DR OMA; YTIPYFP; -.
DR Proteomes; UP000000542; Chromosome 35.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd01876; YihA_EngB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030393; G_ENGB_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11649:SF72; G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11649; MSS1/TRME-RELATED GTP-BINDING PROTEIN; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 83..202
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
SQ SEQUENCE 620 AA; 69132 MW; E90230000CD8F617 CRC64;
MHKPTEATRQ QWKHRLRERT LQRRRNIASK EAEVQRSLKE VTSSRDLIIA QLADQIFSKG
HRHVASAMNI GFVPDGNPAT PLVALAGREK CGKTSLLRSL FRSAREVGRS NRHLRRDAMN
FFNVGGVFNV VDLPGCGGTS VPWSTVLQHA VLLRNFARCQ PSLKMLYYCM DTHYKHGLYI
QDIDLLQFLA REVPNFTIVL TKADQINDRA IRTVHMEDIR KELIYHGIHH PVLVTSAFHM
GGIDTLRYDM VMSSVHTLPT ERLTLTEAQR LSARLFSQKE LSTIRPLAIA PSQVDDETRE
WNEEVRLRER AGDSSVGASV ADAAMGTAED ASLVTEATEE ELRYSEAESA EFAAADDGTS
AAVAPAPARA STAESLLVEL ALPPEEVPLP VDASRDASSS STHIPVVFKD HVTQMAYERV
VRTLRNRPLL QYVDATSPWR NPLRWPRHVV PTKHPKANIM RCPEAPENPY LFQSQFVAPR
ADMYFRRPNV GARKSSQKGR YEADKPLAFL VKAYTIPYFP DILDTAMQPT PWAFLGSREA
YYECNGGRQL GVRLANYATA GSVNPLSDNP APQEPELANE LQALETKRYG APIAMLRPPD
AKLAPSAFPL DAPSSPTLST
//
