ID E9AGJ5_LEIIN Unreviewed; 971 AA.
AC E9AGJ5; A0A2K4YP57; A0A381MCZ7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBZ08495.1};
GN ORFNames=LINJ.12.0910 {ECO:0000313|EMBL:CBZ08495.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CBZ08495.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CBZ08495.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CBZ08495.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CBZ08495.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CBZ08495.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JPCM5;
RA Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P.,
RA Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K.,
RA Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow genomic structural
RT differences between species and strains of Leishmania.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR796444; CBZ08495.1; -; Genomic_DNA.
DR RefSeq; XP_003392347.1; XM_003392299.1.
DR AlphaFoldDB; E9AGJ5; -.
DR STRING; 5671.E9AGJ5; -.
DR GeneID; 10966404; -.
DR KEGG; lif:LINJ.12.0910; -.
DR VEuPathDB; TriTrypDB:LINF_120017500; -.
DR eggNOG; KOG2063; Eukaryota.
DR InParanoid; E9AGJ5; -.
DR OMA; LFRLPNF; -.
DR OrthoDB; 170326at2759; -.
DR Proteomes; UP000008153; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF10366; Vps39_1; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 971 AA; 106360 MW; 7DB3C2895F8E62AF CRC64;
MQAEEAGHAS LRIEAYRVVS LGGPIPHKIE SITTYRTLVF VGTSDSKLLA YRVGACDGSA
ASLTLLQEIT DSRRHAVRQL TVIGGRRLLV LVGDVITVYH IHDDAASSGR GFQLRDVTTI
TGLKDTVAFH VKQHRGVVSM AVLQRKRVTF FEASHTNLDF LLSATVVLPD GVKTLSWMGR
SIVLGGRKEY LLCNPSTAST AALYPTPRSG AAPLVLPMTP VPEVLVASDG AGLRALLYDG
SEVPGDSRVL WATPPAEMRY EHPYVVSYHP SAPHQALQVR LPLLTTLEDA TTYPRSCLYQ
TIDLPKVVKV AQCHWIDYDS AMPSKTAPPD VLSHSPIVVA DADHRLYFLA RTSVTGQAEA
LAAAKLFAAA DLLCRLCPHE VAPMTLRQIV ISGALHKFIR HQDYVGCFHD LSSVESDPRV
AIQLFPGFLR PDEATPSCPA LPLAAPAAVV AAALPALVEY LQSQRAALVL LSGCEPAEPV
QAQLKAVDRA LVMSFCATER EEALLELLRG ENACDAADVA AILRERRQWV ALTLLLEAHG
QYEEAASQLR DLASTRDAET EALQAQSGAL KELFQRHPFS AARLDAYAPQ CTIREWLTSR
SSAHLLSAAD STAMCTVATA MMTALSFFRR RPLAQFYSLF EKHSSWVLGT VPADIAVRIF
FSEANAPHYT AALQVLQTYT ENPSTTPRLM LVVEYLFQLF ADARAHVTEP AVYERYWRGL
GELLFASPVK TVTSVEERQR LRDRLREFLL NSPHVNLESA EAYFDAADIR SACLPERAAV
HRRKGSHRAA IRMFLNESER LDDATAYARS VYADGSSDAY TALLEALLRP AAGTPRVTEA
LEVMNTCDGV DAAAVLPMLP DEMPFAQVSS FLLHALRANT TAYRASAVYS AILKARTLQG
QESRVHLSSR AVVLEEGMVC PVCQRRLRPD TVLAVYPDNV VLHHGCACDE HVCSATLRDY
RHDAYAALED L
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