ID E9AH45_LEIIN Unreviewed; 977 AA.
AC E9AH45; A0A2K4YV37; A0A381MIF2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN ORFNames=LINJ_24_0330 {ECO:0000313|EMBL:CBZ08714.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CBZ08714.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CBZ08714.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CBZ08714.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CBZ08714.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CBZ08714.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JPCM5;
RA Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P.,
RA Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K.,
RA Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow genomic structural
RT differences between species and strains of Leishmania.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; FR796456; CBZ08714.1; -; Genomic_DNA.
DR RefSeq; XP_003392546.1; XM_003392498.1.
DR AlphaFoldDB; E9AH45; -.
DR STRING; 5671.E9AH45; -.
DR GeneID; 10966237; -.
DR KEGG; lif:LINJ_24_0330; -.
DR VEuPathDB; TriTrypDB:LINF_240008100; -.
DR eggNOG; KOG2126; Eukaryota.
DR InParanoid; E9AH45; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008153; Chromosome 24.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 977 AA; 105941 MW; 9803CC4416FBEC52 CRC64;
MTRYQRFSWC PVLLVMALYT GSVLLFTTSM LSTSTVMRTV ATEPCSGTKV PPADQVILIL
IDALRPDFVL SSLRPFARTG GQCTAHEDAL GRQRLDGVYT GPTLHYVEES LRSSRSASVA
FFLVADAPTT TAQRIKAIAT GTMPAFLEAG SNFNSEAIEL DSILRQVNGS AVLLGDDTWE
KMFPNTPARR HWKRAVGIPS FDVADFDTND NAVLAEVYSV LAAETPEAVS RASFGSHAEA
EEQEGHARLV VVHFLGIDHV GHRVDSDNPF MNGKILQLDQ MLRNVSRTLR ERATSMNTML
LVLGDHGMTN SGDHGGGSAQ ETDTFLFAEY FSGTESGATH AHSRSSPGAS LAKAQAIIEQ
RWRDGVDTEF DRLRSCHAHA GVPRDRLGAT YQVDVTATVA VLLGRPIPYS NFGRVIPEVM
VLANSSADID AVERCNLRQL QRYFKESEMK VPRDASWTRP GISVTQQLAD MSLYARRTRT
DMSRLGMFLG STGLLLCAMS LLWSPTIRAH VLPCSGAGWF MRWTALTLLL RLCSVFSNSF
VVNEDSEVLG LLSSLLVFLL ASRVSDSWTQ RRLSRAGPSS PDDGAKLTTA QQSYRLTALD
GICRVATILP RETIFLGLLA VGLRLGVPML LRYRAHITHT VDTESAVDRV LLRLPAGLRF
ERVGIAFGGV AWSALYPHHV GRTTVVVTCA CLALVYHVPV AHHAVPLLCI AAYPLACKWA
SSSSVLQRRA RSRMTSLAAA SGHTAYAYLV TVLWLSSLCN ERVGTAIVVA LYGTSLPSLC
CLLRVEPVLT QGVVLHLSAF VAFFAEGHQC MLNTIDWSSS LVGMHGYNMY AGGALVLSRT
FHAFLLVPFA LRAWPGAVAA AAVAKVNDSH IDGAACEEAR NGHSSAATVA LPMPAPRAGV
SAAVVITVYT YIMLAQSAIS CFNGYIQKTH LMLFPVFCPK LLFDGVIALL TCAAALLALI
RLPPSRHCVV FPPLTSE
//
