ID E9AI17_LEIBR Unreviewed; 1112 AA.
AC E9AI17;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Potassium channel subunit-like protein {ECO:0000313|EMBL:CBZ14409.1};
GN ORFNames=LBRM_01_0780 {ECO:0000313|EMBL:CBZ14409.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CBZ14409.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CBZ14409.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14409.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CBZ14409.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14409.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR798975; CBZ14409.1; -; Genomic_DNA.
DR RefSeq; XP_003722937.1; XM_003722889.1.
DR AlphaFoldDB; E9AI17; -.
DR GeneID; 12983287; -.
DR KEGG; lbz:LBRM_01_0780; -.
DR VEuPathDB; TriTrypDB:LbrM.01.0780; -.
DR VEuPathDB; TriTrypDB:LBRM2903_010014200; -.
DR InParanoid; E9AI17; -.
DR Proteomes; UP000007258; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF37; CHANNEL (CAKC), PUTATIVE-RELATED; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000313|EMBL:CBZ14409.1};
KW Ion transport {ECO:0000313|EMBL:CBZ14409.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000313|EMBL:CBZ14409.1}.
FT TRANSMEM 129..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 284..350
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 1056..1110
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
SQ SEQUENCE 1112 AA; 122325 MW; 02D62805E604D3C3 CRC64;
MSGASPATPT PNDAPPPITI AAASFTAEDL NASTTAIPVA KGSAHLNAKL LMVNLGQDVQ
ATVLNRFRNL QGTIHSQLRN LQNNVANLHH STPASRLSHC RTAGSTTTTN SALAIHSLRK
LFDVIEQRYS HVSILLLLCN VGFEAAAFGI YLHVQSNHIT ENWREFDWGL RYFIAEVLLS
AVFMASWISL LAVEAKKWAY VLTARSLMNY LSSGWMLLLA LGALLTLDRA WTRVYAPMFL
RVWWLHESLL SLLHYPQISA HFTENRLEMV RSMIQCIAVI GISVGILQAV ESFCGDPVEY
FEMVYMMLLS FSSIGYGDVT PLTVQGRLLM IVFIGVGFSY FVPILQYVAD LGVYHLSHAY
YTTWLKRTDH VVICGNLGYN ELRMQLKNIF AEDRHYLKMK VVLLLREQPS AQVLLLLNSP
KYRSAVHLLV GDPGVPTDID RCNARGASAM FLLGAGTNSS YYSDYDLAAQ AMTVSALVPD
LPLYILLHRS RYTKSLMPSR ANVLEFERLN HNLLGLGCVL PGMIPFVANL MRMFDPMTTE
ALWELRDLKD LFGFRGSKAS LRAMRKMWTP KRAMLTYGAA TIELGNGAEP DWMSTYEASL
AQHVDTVAAP TPVQRGHYTV VSLARLLYST DITLIGVVRD SGSGDSIVDL APRGSLVGVQ
KLIVICDVRR AAQGVVDEIV HDALLHPTQR GSPTSAKMPQ HELLHNPKQH PHRRSDSASS
AAATAATVLG AGAVERPRRQ PRVEAKRDAE GRMPLAAVSP VPSAAADDED ALIEALVSPV
LLDAGRLGSL ACESASAGAP VTVTQSSPVF PVPTAAHSVL RVESDVRHLA NHYVFIDLSS
AHERTNWSPE AAVESRTAKA ADYYDTMRPV RQHNPDSDIV LLASDTNYDS LNNMWEEEDV
TGSLIVVQGC GLFTSDLRRC NVAKAAAIVI FSAGDRCDDH GDSLSVLVMQ LVRQLIDEDK
HNGAADIPIV VEVDHAELVP LFGPATTVGK DAKTSEWVLE PSFMSGCVVC RHMLDTGLQE
MHFTPELLHV LEQLLSSKSE SLLVTVMAPD AAWVVYEDAT SFGLDNALLP LAIHRFHEIL
RDNNSIPFRY IITNPPPSFP LHSDDFIYCL KL
//