ID E9AI33_LEIBR Unreviewed; 615 AA.
AC E9AI33;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Putative histone deacetylase {ECO:0000313|EMBL:CBZ14441.1};
GN ORFNames=LBRM_08_0840 {ECO:0000313|EMBL:CBZ14441.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CBZ14441.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CBZ14441.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14441.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CBZ14441.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14441.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798982; CBZ14441.1; -; Genomic_DNA.
DR RefSeq; XP_003722953.1; XM_003722905.1.
DR AlphaFoldDB; E9AI33; -.
DR STRING; 5660.E9AI33; -.
DR GeneID; 12983533; -.
DR KEGG; lbz:LBRM_08_0840; -.
DR VEuPathDB; TriTrypDB:LbrM.08.0840; -.
DR VEuPathDB; TriTrypDB:LBRM2903_080016000; -.
DR InParanoid; E9AI33; -.
DR Proteomes; UP000007258; Chromosome 8.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 209..512
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 615 AA; 67064 MW; C0A131D3DB5FF74E CRC64;
MCVAYRASPM PPSRFARHES SGTVIVRRFQ FPHHETEAHI RKGHLREPLE AVASRVGLRA
RCSTGPSFAD LCLVDNQELL LMGKLVDRGV YYITGGTCTD VEGDGSPRST KSTILNSATC
GVAPQPPDIT VGWCFDARML LHRSEINRSP ETPHRLQRAI ETLQACERAC DILPVELLAP
FRVHIDGSLE PDLGRVAPSI SAANRAQWIP ARLATYDEVC SFQDPRVYHD FLKSGASLVS
LKSDVYCSDE ASSVAARLSA AAVIDASVAA LRGVAAIRSG GTSSATGCVL PLVSFCLVRP
PGHHCAASQP SGFCLVNNVA IAAQQLRTRH ASVLPSGPPR IAILDLDVHF GEGTASFVEG
ACDPTSLLYL SLHRYDKKSF YPFDSRGDTS YVGGSRHTAS KGSICNVAVH TNAQHPTQCE
QVISDHLMNS VLEEIFLRRL AQFRPDLIMV SLGFDAAYGD PLGKMAVEGG FASVLSRLKE
WCLHEGRSVG LVVALEGGYN PEAVAQGVLS VALALSLPRT DPLLQQLLVE RPPKVWADLR
QRQERRHREW QNLRRERAEE GIGGLLIGQS SEMKPPASEE PEKPQEDALL LDRHRRWCAA
LVAKVQQIHR DAMAP
//
