ID E9ALK7_LEIMU Unreviewed; 445 AA.
AC E9ALK7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Rab GDP dissociation inhibitor {ECO:0000256|RuleBase:RU363124};
GN ORFNames=LMXM_08_29_2160 {ECO:0000313|EMBL:CBZ23812.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ23812.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|EMBL:CBZ23812.1, ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|EMBL:CBZ23812.1,
RC ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the Rab GDI family.
CC {ECO:0000256|ARBA:ARBA00005593, ECO:0000256|RuleBase:RU363124}.
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DR EMBL; FR799561; CBZ23812.1; -; Genomic_DNA.
DR RefSeq; XP_003872341.1; XM_003872292.1.
DR AlphaFoldDB; E9ALK7; -.
DR GeneID; 13447130; -.
DR KEGG; lmi:LMXM_08_29_2160; -.
DR VEuPathDB; TriTrypDB:LmxM.08_29.2160; -.
DR OMA; FETKAKM; -.
DR OrthoDB; 8704at2759; -.
DR PhylomeDB; E9ALK7; -.
DR Proteomes; UP000007259; Chromosome 8.
DR GO; GO:0005093; F:Rab GDP-dissociation inhibitor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR Gene3D; 3.30.519.10; Guanine Nucleotide Dissociation Inhibitor, domain 2; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018203; GDP_dissociation_inhibitor.
DR InterPro; IPR000806; RabGDI.
DR PANTHER; PTHR11787:SF8; RAB GDP DISSOCIATION INHIBITOR; 1.
DR PANTHER; PTHR11787; RAB GDP-DISSOCIATION INHIBITOR; 1.
DR Pfam; PF00996; GDI; 1.
DR PRINTS; PR00892; RABGDI.
DR PRINTS; PR00891; RABGDIREP.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
SQ SEQUENCE 445 AA; 49863 MW; 8621EBA157BB1F81 CRC64;
MEETYDAIVC GTGLVECVLS GLLSVNGYKV LHVDRNAYYG GESASLNLEQ LYQKFNKGKP
PAFLGRSHLY NVDLIPKVLM CAGELVKILR ATVVDRYNME FMLLDCSFVM KDGKIAKVPA
TEMEALSSSL MGFFEKRRLR NFLQYVSNYN VKDSRTYKGY NLQTMSMQQL FKEFDLGADT
ISFVGHAMAL QNNEDYLHKP AIDTVMRCKL YENSFLMYNR SPYVYPLYGS GELPQAFSRL
SAVYGGTYML QTPVDKVNFD ANGAFESIES GGKKAFAKLV VGDPSYFPDR VRSCGQVVRC
IAIMDHPIPN LKVTANACQI IIPQSELRRK NDVYILQLCE EDKVCPEGKF IVMIGTVVEH
PGNPKADLEA GLKLIGPTLE TFISVSDLYE PLEDGSTSRC FISKSYDAAT HFESAAEDIL
NLFERIHGKP YSFDAIKRTG EEVHA
//
