ID E9AMI1_LEIMU Unreviewed; 545 AA.
AC E9AMI1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Stress-induced protein sti1 {ECO:0000313|EMBL:CBZ24136.1};
GN ORFNames=LMXM_08_1110 {ECO:0000313|EMBL:CBZ24136.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ24136.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|EMBL:CBZ24136.1, ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|EMBL:CBZ24136.1,
RC ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FR799561; CBZ24136.1; -; Genomic_DNA.
DR RefSeq; XP_003872662.1; XM_003872613.1.
DR AlphaFoldDB; E9AMI1; -.
DR GeneID; 13447290; -.
DR KEGG; lmi:LMXM_08_1110; -.
DR VEuPathDB; TriTrypDB:LmxM.08.1110; -.
DR OMA; MYSAREN; -.
DR OrthoDB; 1343678at2759; -.
DR PhylomeDB; E9AMI1; -.
DR Proteomes; UP000007259; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.260.100; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR041243; STI1/HOP_DP.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22904:SF523; STRESS-INDUCED-PHOSPHOPROTEIN 1; 1.
DR PANTHER; PTHR22904; TPR REPEAT CONTAINING PROTEIN; 1.
DR Pfam; PF17830; STI1-HOP_DP; 2.
DR Pfam; PF00515; TPR_1; 3.
DR SMART; SM00727; STI1; 2.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 3..36
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 71..104
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 131..170
FT /note="STI1"
FT /evidence="ECO:0000259|SMART:SM00727"
FT REPEAT 222..255
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 357..390
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 391..424
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 425..458
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 493..532
FT /note="STI1"
FT /evidence="ECO:0000259|SMART:SM00727"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 62095 MW; 4AB8B1737037F885 CRC64;
MDATELKNKG NEEFSAGRYV EAVNYFSKAI QLDEQNSVLY SNRSACFAAM QKYKDALDDA
DKCISIKPNW AKGYVRRGAA LHGMRRYDDA IAAYEKGLKV DPSNSGCAQG VKDVQVAKAR
EARDPIARVF TPEAFRKIQE NPKLSLLMLQ PDYVKMVDAV IRDPSQGRLY MEDQRFALTL
MYLSGMKIPN DDDDEEERPS AKAGETAKRR EERALTDNER EALALKEEGN KLYLSKKFEE
ALTKYQEAQG KDPKNTLYIL NVSAVYFEQG DYDKCIAECE HGIEHGRENH CDYTIIAKLM
TRNALCLQKQ KKYEVAIDLY KRALVEWRNP DTLKKLTECE KEHQKAVEEA YIDPEIAKQK
KDEGNQYFKE DKFPEAVAAY TEAIKRNPAE HTSYSNRAAA YIKLGAFNDA LKDAEKCIEL
KPDFVKGYAR KGHAYFWTKQ YNRALQAYDE GLKVDPSNAD CKDGRYRTIM KIQEMASGQS
ADGDEAARRA MDDPEIAAIM QDSYMQLVLK EMQNDPTRIQ EYMKDSGISA KINKLISAGI
IRFGQ
//
