ID   E9ANQ7_LEIMU            Unreviewed;       445 AA.
AC   E9ANQ7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein {ECO:0000259|Pfam:PF02096};
GN   ORFNames=LMXM_11_1180 {ECO:0000313|EMBL:CBZ24569.1};
OS   Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ24569.1, ECO:0000313|Proteomes:UP000007259};
RN   [1] {ECO:0000313|Proteomes:UP000007259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family.
CC       {ECO:0000256|RuleBase:RU003945}.
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DR   EMBL; FR799564; CBZ24569.1; -; Genomic_DNA.
DR   RefSeq; XP_003873084.1; XM_003873035.1.
DR   AlphaFoldDB; E9ANQ7; -.
DR   GeneID; 13454878; -.
DR   KEGG; lmi:LMXM_11_1180; -.
DR   VEuPathDB; TriTrypDB:LmxM.11.1180; -.
DR   OMA; RDFFRFP; -.
DR   OrthoDB; 5395681at2759; -.
DR   PhylomeDB; E9ANQ7; -.
DR   Proteomes; UP000007259; Chromosome 11.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   CDD; cd20069; 5TM_Oxa1-like; 1.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR028055; YidC/Oxa/ALB_C.
DR   PANTHER; PTHR12428:SF13; 60KD INNER MEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR12428; OXA1; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003945};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          163..359
FT                   /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02096"
SQ   SEQUENCE   445 AA;  50589 MW;  27D974A5B43E2E3E CRC64;
     MLLGSRLARA PAAVSATTFL HSCPPATPAC RLPSTHHNHA PTFSSLFSSI ACGHGVRSGR
     CSSGMVVALH VQQRGISWNP LKWGRTDVGR STNPQLEEEL PEIFAAQPTE VDDYICPDKS
     LFERLEDFWD WAVSFLQPVE KQVEIMRSLR HDGFMSFDLG GWGHVFFFYG LCMRLLTLIP
     SLYSHRNSLR MAHIGPQISE ITNNQNKAKN DRTLSSAEKR VIKDGYNRMK YALCKKHKCS
     QWKSFLTTFT MPITMSAFLS IRRLAMYETD LEMAPFLWVK DLTMPDPTYA LPAICAGMFL
     LNFEMNQRMQ RGGRSASGLY VRWAVRASSL VGIYFFAGQP SAMFAYWIGL STAGLLQPIL
     LRWQPFRDFF QFPDPPQAAK SNIISEIKGP SLYERLFATQ EEKTRLEAQR KAERIKNSAA
     RIETVDNYEV VFDDDVKEKP LGNRR
//