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Database: UniProt
Entry: E9AY21_LEIMU
LinkDB: E9AY21_LEIMU
Original site: E9AY21_LEIMU 
ID   E9AY21_LEIMU            Unreviewed;       510 AA.
AC   E9AY21;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=RNA uridylyltransferase {ECO:0000256|ARBA:ARBA00012472};
DE            EC=2.7.7.52 {ECO:0000256|ARBA:ARBA00012472};
GN   ORFNames=LMXM_26_0390 {ECO:0000313|EMBL:CBZ27862.1};
OS   Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ27862.1, ECO:0000313|Proteomes:UP000007259};
RN   [1] {ECO:0000313|Proteomes:UP000007259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide;
CC         Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173116; EC=2.7.7.52;
CC         Evidence={ECO:0000256|ARBA:ARBA00024498};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; FR799579; CBZ27862.1; -; Genomic_DNA.
DR   RefSeq; XP_003876343.1; XM_003876294.1.
DR   AlphaFoldDB; E9AY21; -.
DR   SMR; E9AY21; -.
DR   GeneID; 13449264; -.
DR   KEGG; lmi:LMXM_26_0390; -.
DR   VEuPathDB; TriTrypDB:LmxM.26.0390; -.
DR   OMA; WVERTTY; -.
DR   OrthoDB; 1080369at2759; -.
DR   PhylomeDB; E9AY21; -.
DR   Proteomes; UP000007259; Chromosome 26.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0050265; F:RNA uridylyltransferase activity; IEA:UniProt.
DR   GO; GO:0071076; P:RNA 3' uridylation; IEA:UniProt.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.50; -; 1.
DR   Gene3D; 3.30.70.1970; -; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002058; PAP_assoc.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   InterPro; IPR041060; Ret2_MD.
DR   PANTHER; PTHR12271; POLY A POLYMERASE CID PAP -RELATED; 1.
DR   PANTHER; PTHR12271:SF50; RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 2; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF03828; PAP_assoc; 1.
DR   Pfam; PF18528; Ret2_MD; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBZ27862.1}.
FT   DOMAIN          88..148
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          188..280
FT                   /note="RNA editing 3' terminal uridylyl transferase 2
FT                   middle"
FT                   /evidence="ECO:0000259|Pfam:PF18528"
FT   DOMAIN          387..447
FT                   /note="PAP-associated"
FT                   /evidence="ECO:0000259|Pfam:PF03828"
SQ   SEQUENCE   510 AA;  57702 MW;  B068869007927A52 CRC64;
     MYAPTPLRLY VAVTRGLCSS AVAASSSTDA ASSPNVASSS ASEGVSYASH LVASKDHYAQ
     WGRVLLEENR KRIGPEQMFR TAIRAQQQLQ MLADKWTPDA KIYCCGSLVT HGQMEWGSDL
     DLACVFDDPY PDHSVQAKRT EKLWSVVKRY VPQFLRSNLL ALTEARTPVV KLRYVNDDKV
     ARGRYAVLTE EEDRKSRTTL WDIRNRHLDS KDLEYIATKM GRENIEGIWV ERTTYGCRCA
     VQCTSREQAI EAVGFFPDGV IMTKGMREDY TRDMLDLRYV PEMFMYKWDI SFVAYGVKNS
     YLLRHYLHSG PPAARHAAMA AKAWGKASGV GLGTAAMLTS YAVTVMFVHY LLATRQLAWI
     DPWSLAHPVH MPRFPDFSPL LDCDPVELGK LLHGFFTYYA AHFNYEKNII SLSRPRLSLR
     SDVNWNFPQS KQGTFSYLLG IEDPYEDVGI GGLNLGRHLH AAKFNQVKQE FARAAATMER
     YVPSNAPEKT ILGARRGGTS NHHHHHNRFD
//
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