ID E9B012_LEIMU Unreviewed; 450 AA.
AC E9B012;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Putative zinc transporter {ECO:0000313|EMBL:CBZ28563.1};
GN ORFNames=LMXM_28_1930 {ECO:0000313|EMBL:CBZ28563.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ28563.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR799581; CBZ28563.1; -; Genomic_DNA.
DR RefSeq; XP_003877034.1; XM_003876985.1.
DR AlphaFoldDB; E9B012; -.
DR GeneID; 13450737; -.
DR KEGG; lmi:LMXM_28_1930; -.
DR VEuPathDB; TriTrypDB:LmxM.28.1930; -.
DR OMA; VGFMNAV; -.
DR OrthoDB; 153852at2759; -.
DR PhylomeDB; E9B012; -.
DR Proteomes; UP000007259; Chromosome 28.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR11040:SF44; PROTEIN ZNTC; 1.
DR PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR Pfam; PF02535; Zip; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 47..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 46892 MW; A00C589E38709758 CRC64;
MAQPTLTVLR QLAGDLVRAA VAVQAREPLE FQSAVASATK TVAYSQVRAG SHSSAKGDGT
RSRLSYAESA HDHGHSHGSG SDGGHGHSHG SGSVQGDYML GLHIAAIFII LAASAVGTLI
PIVGKRVPAL RLHAYVYAVG KSAATGVVLA VSMIHMISPA SVVLGADSIP ESFREMYEGW
AFLFAMMAAI VMHAIDGTIG WIAERWSARA AGKALPADPC HDSLCNECVA VRKGVPSTRP
DEDALQDMHG CVEDGQGCAS VPQMDAEACG GHQHGVAVPE DMAPLQRVVA AVCMEFGVTL
HSVFVGLAVA VSNGTDLRAL IIALVFHQLF EGLAMGARLA DASFKISLEL ALMLVFSFSA
PIGIAAGTGA VMASRDALSG TTYALVSAIL DSICGGIMLY IAFNLLFVDF PHDLHVHCGV
KSKRGVAKRI GMYAGLWIGA GVMAMIGKWL
//
