ID   E9B344_LEIMU            Unreviewed;      2035 AA.
AC   E9B344;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN   ORFNames=LMXM_31_2650 {ECO:0000313|EMBL:CBZ29660.1};
OS   Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ29660.1, ECO:0000313|Proteomes:UP000007259};
RN   [1] {ECO:0000313|EMBL:CBZ29660.1, ECO:0000313|Proteomes:UP000007259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|EMBL:CBZ29660.1,
RC   ECO:0000313|Proteomes:UP000007259};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR799584; CBZ29660.1; -; Genomic_DNA.
DR   RefSeq; XP_003878112.1; XM_003878063.1.
DR   GeneID; 13453705; -.
DR   KEGG; lmi:LMXM_31_2650; -.
DR   VEuPathDB; TriTrypDB:LmxM.31.2650; -.
DR   OMA; EPCMPNS; -.
DR   OrthoDB; 7433at2759; -.
DR   PhylomeDB; E9B344; -.
DR   Proteomes; UP000007259; Chromosome 31.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0016423; F:tRNA (guanine) methyltransferase activity; IEA:InterPro.
DR   GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR   CDD; cd18091; SpoU-like_TRM3-like; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR045330; Trm3/TARBP1.
DR   InterPro; IPR044748; Trm3/TARBP1_C.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR12029:SF11; METHYLTRANSFERASE TARBP1-RELATED; 1.
DR   PANTHER; PTHR12029; RNA METHYLTRANSFERASE; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
PE   4: Predicted;
FT   DOMAIN          1878..2020
FT                   /note="tRNA/rRNA methyltransferase SpoU type"
FT                   /evidence="ECO:0000259|Pfam:PF00588"
FT   REGION          82..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2035 AA;  220517 MW;  A5D15C1FC8ACD214 CRC64;
     MSSPSLFVAL VDQLATRCDS GGSGSGTSHT QDVGEHVSRL FLLACDLTTA FRPADLYQHL
     EGMMTREWAA LLHGECLHTS SPASSDALKP ATLSHSSPPP ERAPTLIAAS GALLGYASTH
     VTEFEASGVG QEWVDYVCAR WQSSVLQLLS AQPPFSADAR TAVCYTVAQL SLLPRNCCEQ
     VLHAACEALE TGREDGLNAS IATELLGQIT SLMVVCRPFQ LHGLALEDPA AAAASAATSC
     SAAASKKVTA STTGAQTWKR AKLSTQRPAG EGTGAGASEC STAAIGSEAP TASCRAIPSC
     YPFPSTERLK ELKVSLIQCC LVSLGATVAE ASTASNTAVR ATRAHRGQQL QQQHRTVPVA
     LICQRVLIPL LLLDGGQGLG PYEHLVHNLL CTLANRPNTL STTAAVSPDS SHRTPGAAAE
     DAVLLLHGDN CDEVVLLIAA LFDFLFRQPS LDPRTDFRFS GFLWTVLSSA LHRSLTATET
     DAGHRANMQL RVVYLLKRIV YMTKQEQQAR QSTDSPSVAL PPIIEFHPLF HWCTATSGIG
     SAAAAAHGDS LSSTTWDNFF LVLESLNEYG WHIIEPVMAR LDTLIAQLDS WLESAASPWD
     GTAASTISVS AAALHPRWIE ILLLKLILHP NLGVRKVGLR RIWALPQRVL RSLSSSFLFQ
     YAFQSASDPR LCGDIDRVPI TASFLDTKAF EGTEVKAVPD VEPLAQEVEC FYASLFAHRW
     SSGDADAVAG RIDALHRMLD TAIKKPPRFT VCTLARVLLA IAQVFLDQGI DAEPVLLDEG
     VLERLHRFMR DSVQENVPFW LDVRVTVILF AALTTLAAAT ASPRRCRLHL AFWRLYCMCG
     PLGESGGHSI ANVDACGQYG LVGATVEERF LQHWLVQLSA RQQPMRQVSF NEAAPSLVDA
     LLDVEGLACR VEALLRAPSE PGSHEVVNIV AVKETFFLVG ALTRTGSVRH AELVRAVGDR
     IATTIASLQT RAYCTAAHVL ASAACLVEFQ HSVGGAVCAQ LWPANTTLQS MASALHGHIM
     AALQASLQSI CGAAEVPGKA RTAPSLFESE THDEADITWA LMNITNFDVV AAAITSLNAI
     ACDPMTRTPA AAAAAAGALN APQHVRQLIC LLRECSAAYE STSVSGAGTA GGEEAGQERL
     AALLIVSRNA ARLLQSELCG YLSLKHEEST APQAQHDEGL GVVGQGRLLF PTALPTCREA
     PPFSAAASSR CPIAVVLPRD VLEMYVDQLM ALPSQRVPSG AVPSALSHLP WSTLLSQQGR
     YVCNALYLLL LSLTAAEQEG TNTAASTSMR TSPKLVGRVQ DYALSQLGEC WTVNLASVYD
     VLLWVASSNV PEVVDYVAIA NGMWEHMREV GARQYTRLAA LAFTVLHYVM PHHPDYVKEV
     LLRVLQGEGK DAQTADRDVY FAAITASLQV LHDPANNWPV LRDVVLYAAV LFNTNRDEEE
     NESTVAVTEP LLWTWPEALR LCYPPTTCMA AVGRAMAVAT LLWCCHESVA GRAVPLTMEL
     LRMNTCHPVV THEPCMPNSR THRTRMRLWQ LLCALLPCLA DQHAVPPAQV EEVFRMLVFH
     CLTVNNMGSV RRLMELYAIR LVEQRPSLYT VLSEALGSYS LRPQVCGSYI LIACHVLLRQ
     EEAGGAAESA AAAAGDEALA SGIFTSLFPR ILQQSTSNQH LLRIISHIGL FNICQRRLAR
     GRPISPAVAA IYEYVLQALE HVKFREKHES MLFFDTEEAS SPRSLFCVQR KEANTVLAEV
     LPAAAFERLR FVETEMCCMI GALYPMELLR VHDWCASLRV QERVSVLKGF RGIPHTSTPS
     DYYVDYTREA TELLTRDPML EASAAAATAR SAGVGAGEEA GGADGATANV QKKVSSWWTS
     EVYNELHPRA LRTQKQSIIV VGSLLENPVN IAGLCRCGEI FAIESIVVPE KKVFEHPHFV
     AAARSAELWI PWEEVVPKDL PYYLEGLRRR GYVVVGIEQT AASVPLEQFS FPERCAVVLG
     AEGQGVPAPL IPLLDVCVEI PQYGLIRSLN VHVAGAITMY EYTRQHLMAQ PHPST
//