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Database: UniProt
Entry: E9CM35_9GAMM
LinkDB: E9CM35_9GAMM
Original site: E9CM35_9GAMM 
ID   E9CM35_9GAMM            Unreviewed;       225 AA.
AC   E9CM35;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158,
GN   ECO:0000313|EMBL:EFW12429.1};
GN   ORFNames=SSYM_1345 {ECO:0000313|EMBL:EFW12429.1};
OS   Serratia symbiotica str. Tucson.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia; Serratia symbiotica.
OX   NCBI_TaxID=914128 {ECO:0000313|EMBL:EFW12429.1, ECO:0000313|Proteomes:UP000013568};
RN   [1] {ECO:0000313|Proteomes:UP000013568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson {ECO:0000313|Proteomes:UP000013568};
RX   PubMed=21266540;
RA   Burke G.R., Moran N.A.;
RT   "Massive genomic decay in Serratia symbiotica, a recently evolved
RT   symbiont of aphids.";
RL   Genome Biol. Evol. 3:195-208(2011).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; GL636109; EFW12429.1; -; Genomic_DNA.
DR   EnsemblBacteria; EFW12429; EFW12429; SSYM_1345.
DR   Proteomes; UP000013568; Unassembled WGS sequence.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-HAMAP.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000013568};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013568}.
FT   DOMAIN        8    204       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   225 AA;  25792 MW;  D3FD1AAB72ECEB60 CRC64;
     MPLYLPDDET FDSFYPGENP SLLAAIRSAV CQEHGSYIYF WSREGGGRSH LLHAACAELS
     QHGEAVGYVP LDKRTYFMPE VLDGMEQLAL VCIDNIEFIA GDEAWEMAIF NLYNRILETG
     HTRLFITGDR PPRQLNLYLP DLASRLDWGQ IYKLQPLSDE EKLLALQLRG KLRGFELPED
     VGRFLLKRLD REMRTLFMTL NQLDHASITA QRKLTIPFVK ETLGL
//
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