ID E9CU62_COCPS Unreviewed; 716 AA.
AC E9CU62;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=ELMO/CED-12 family protein {ECO:0000313|EMBL:EFW22251.1};
GN ORFNames=CPSG_00150 {ECO:0000313|EMBL:EFW22251.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; GL636486; EFW22251.1; -; Genomic_DNA.
DR STRING; 443226.E9CU62; -.
DR VEuPathDB; FungiDB:CPSG_00150; -.
DR VEuPathDB; FungiDB:D8B26_001034; -.
DR eggNOG; KOG2999; Eukaryota.
DR HOGENOM; CLU_009191_0_0_1; -.
DR OMA; WESHARP; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771:SF56; CED-12; 1.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
SQ SEQUENCE 716 AA; 81229 MW; BA67578E9A0F68C7 CRC64;
MENINVSELA ERLGSDEDAV RKMAVFKLQS NIGDPSFADV FISEKGLVKL KHLAMTATGN
TLAYSLTSFA RLLEVDKGWE VVDEEFIERI VQLIVTHPLV NILRGAMSIL VSIVSHPHSS
GRASVHSHVG LFGFQALKPA IAIHSQFLEM LVSRLSSADH ALCANSLQLI NSLMRDSIIS
ESEAEWPKFI KRLQDLGVIR AVYVLMQSSA LQDLAQPLLE FQSLTKVLLK KWRDFPVELE
NTEHRRALKG IHLASNPEKP AQETEKTGSR KHNPHKWRRL GFETESPQWD FHDMGFLGMM
DFTDFVRRYQ DQFQKMLLEQ STRPAEQRCP IARASLTVTA ILYEHFEIDK ADLEDPKSYL
ILESRSNLDK VFKPLLLHWP RLHVAALNAF FRLWKATGAE VEDFSKIAEL VRILVESVVG
GAIRTKDMHE IEEEMNDFEY QRLRELQMEL LELTYEDVWG QHLHQVREEL HHEALQFVKE
QRIRCLLQGA WFPTESGSKG ENGASSKPDM KRTNSTTYRY AQLSHNRRYL HYADFDSVNN
EIPDIDSLTH KIDLNAVSSV VSNVSASSDS SSGSTIKTLA HSSSTTKITI HGYVQSPSSS
SNNPKSSSDP HNEKANRQRS NTVKTNQTQK EIVLLTLHPQ SHSIASEWLD GLLMLLNQQP
ITAETNKLIN LVSNYGLKIR LLNVRFDDAT FIGECPDIPS REGLDEDYYY DIFGGA
//
