ID E9CVC1_COCPS Unreviewed; 802 AA.
AC E9CVC1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=CCHC-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CPSG_01416 {ECO:0000313|EMBL:EFW21259.1}, CPSG_09932
GN {ECO:0000313|EMBL:EFW13480.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EFW21259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Silveira {ECO:0000313|EMBL:EFW21259.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL636515; EFW13480.1; -; Genomic_DNA.
DR EMBL; GL636487; EFW21259.1; -; Genomic_DNA.
DR STRING; 443226.E9CVC1; -.
DR VEuPathDB; FungiDB:CPSG_01416; -.
DR VEuPathDB; FungiDB:CPSG_09932; -.
DR HOGENOM; CLU_020936_1_1_1; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR025165; DUF4100.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR001878; Znf_CCHC.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF13352; DUF4100; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 367..380
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 664..743
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT REGION 235..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 90228 MW; 7480ABB95A04E21E CRC64;
MAEGTTGSYA TMSLGEDKRI VVHSHIPMPS PGTANAPWFD GRDATLFIER FYQMCKDHGV
IDPKNIIERL ARYCVTWIGE WMKTLEGYKE GNWEVFSKEI IHEFRDQDIT YKIHRRDYLR
AITKKPRAWD GNIRAYVREY TTIASTVQAN GRLDEFTKVS WFLQGLPEKL RNKVIDKAKL
NLSDDMSPID FRKVVRVTMD LIDQYEGNKK VFEEDEMKQK EMEKLGEQYQ LANKPPTVEA
PKKTASFAKT EESESKAKAK GSDSANIEAA IEKMTNEFTN LALAMRVQSN QIQGNSDQYY
MLQREGPPKP IPNYPTNVTV NPTTVQENTQ LPVNPYLARN GSPMTGYSGA RGRGGARTGG
ISTRPSCFYC GKPGHRQSQC YEYQSDMSNG YCHIDDKGNL RMGSKGQNYR AVTPKPGIPN
MYIVRSMGED EWAIPESTSP KKETNQQEET PPANSTSVKV QAGRLAYLMS DGESDSDKEY
EPLEERTSVN VGTVGEAKNN QRAKIATPHT QRTGQFITYR DNQASVDDDV MEDVEPINQK
KPEIQNKSAE KQRPRYSATD RLSSQIRDST DANELMGRIL NGKVELSVKE LIGVSPKLHR
AFFGSGWNNS TSKSHAKVGV SEPVQPELKI NSGRLTSKPM VPKSKTAYGM RSLYAPVTIN
QQELMALIDT GSEINLLSRK YAEMLNLPME NKPRVTMVVQ TGEVAPFYAF CDEVPVQIGD
IVTHTPFLIF EGGDQQLILG RPWQFAACWG CNTSEDGGVN CEIYNEERTR RLVFEGFKPN
SSNMRYATDK SNSDHLNDST GI
//
