ID E9CWD6_COCPS Unreviewed; 944 AA.
AC E9CWD6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Methyltransferase type 11 domain-containing protein {ECO:0000259|Pfam:PF08241};
GN ORFNames=CPSG_01769 {ECO:0000313|EMBL:EFW21612.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL636487; EFW21612.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CWD6; -.
DR STRING; 443226.E9CWD6; -.
DR VEuPathDB; FungiDB:CPSG_01769; -.
DR VEuPathDB; FungiDB:D8B26_001777; -.
DR eggNOG; ENOG502RDBT; Eukaryota.
DR HOGENOM; CLU_005788_0_0_1; -.
DR OMA; FAQAPRN; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
FT DOMAIN 738..788
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 102733 MW; 826537EC92A83E21 CRC64;
MEDSQEARGN YIGRSLHRII TDGQSHRQRY DNSSRAKAKI HPRGAGAHGS SPLAQHGDGN
RFSISSSRRA SCSTDCRARH RDHFDDLYDA TDESDRESCP SLSSQAETGS NSSFTVSDAS
SISKDSRRRT FPTLYIPSSK VGAKSSPLPP TPPPKIPVSP LALAKLPQNV PKIAAPPSLA
GSASEVSDRP STFSTPQTPD LADVPDVNWG EQRLRVRGNL ESGHPSRSAS ASASPRLDVQ
LDAPEDWSAF LGNFPRIPAH AVEDGSSSVC ESDAAPSVES NRGLQLPVAA LAALQRFEVN
SDRFQSRPPS EVGEAKEMHE LLSHMRYKDP GDPLSASAYS GSSFTSLSVP SPGGFFASLK
GQARKTWCFS SANTPTSAMA EKFYDLPWDP QGNTIVEQVV ECPDDGTEGP PTAKALVSGP
PTARKIPAEF AEEAQREGVR DGPDNNNNAN NDNDYDATYA KALKAHSMSN LDRTTLWLAT
QSAYLTGIED KRLNGAVQES LGSAASGKVG ETKPTADHID STKYSERSTK LLSEPPSKPL
PTKEPTFYLG FKHVQQRSQN ADAFLHSNFR FEAMQAARLS MPAKHVDHVA GKYELNNPVR
PPYRGPFAQA PRNSKLTSVL QEQVMFSNVE KEQDALVQLR ASAWAIEALK FLNGGPLVPS
PAAKRMAEAA PPGQPGTPGK RRVKALDLGG QSACEWGWHL ANEYPNVEVF TAVTKDQAVS
PVEAPPNYQH IPVPCLWKLP FKDNQFDLIS ARSLHMLLKS SRPVGARDDE VDMCLKECLR
CLKPGGYLEF FLMDSEIVRA GTYGSATSVE FGFNLKTRGY DPAPTKAFLS RLRKANFGDL
KRAWLFLPMG APYNEHAQVP GIKTPSSPDT AELMGSTADI ASTSGLFGGW MWEQWMLKLQ
MEMGRDNHKL LDETAAVIDE GRKCGAGWRC LSGWAMKPKK KQTS
//
