ID E9CWJ2_COCPS Unreviewed; 833 AA.
AC E9CWJ2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFW21668.1};
GN ORFNames=CPSG_01825 {ECO:0000313|EMBL:EFW21668.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL636487; EFW21668.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CWJ2; -.
DR STRING; 443226.E9CWJ2; -.
DR VEuPathDB; FungiDB:CPSG_01825; -.
DR VEuPathDB; FungiDB:D8B26_001823; -.
DR eggNOG; KOG2068; Eukaryota.
DR HOGENOM; CLU_001793_1_0_1; -.
DR OMA; CNNRNCM; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 18..62
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..208
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 230..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 238..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 90215 MW; 063E95C9189A617D CRC64;
MASRTQNDTV IDDDDEICPL CIEEFDLSDK NFKPCPCGYQ ICQFCYNNIK THSEEGRCPN
CRRVYDENTI QYRVPDADEL KADLALKHRK AAAAKKKEQE KREIEASSRK NLAGVRVVQK
NLVYVIGLNP TIRDENQLLQ TLRGDQYFGQ YGEIEKIVVS KAKPSGNPNQ GIGVYVTFAK
KSDAASCIAA VDGSANGDRV LRAQYGTTKY CSSFLRNEQC NNRNCTFLHE TGEDSDSFSR
QDLSSMNTIS SQRPHPNYPN VSANQSRTYP PGSQSGPSSS LSMQRHTNKD EGTRMPANDS
PALPSSASWA NKDALAHRTR RPSVAASRGT PSPKPATATI ATKPEESRAA TEKRTHQNAE
ESRQHTPTPG PSSRLEQRDS VSPRRPLSVS QDRGMVLYNL VKAINSPEFR FQFSAAGLPA
DELAFIENHP SLIDPYGGVK RRAMREKAEQ ERAKQEVEAK MLLHANQPEE ETLEGGSSQL
GGEPEELHSG PGPAGRSGRE QQAIQPPSQQ ATASSSAVGS PISAGHQFQS LNVNGRALTP
LQQQQLMLLK STTGQQSGLL DQLQTSSING YDHNPLSRPS AFQNQMPPVG AISGHARQSS
RFSFANESNA KNPNHRLLSQ QAAVMQASTT NPMATANTQQ HGLSSHFFTS GVQGPPPGLK
TAGTPPVSGG GMFAQGHGFT STMNNNLGLN VKQDGNADLM RELMRARSGT SGGGVQTLEA
TKREYISPLI HQHSTPPPLA PVSGLLNSLY GPQAGFYQEP GPQKQKKRGK KHRHANTSSG
GGGVVDLADP SILQARMHQN NATAVAGQGL YGSQGQGGYN HSNMVFNGGF ARW
//
