ID E9CZH7_COCPS Unreviewed; 845 AA.
AC E9CZH7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=XPG-I domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CPSG_02464 {ECO:0000313|EMBL:EFW20621.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL636488; EFW20621.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CZH7; -.
DR STRING; 443226.E9CZH7; -.
DR VEuPathDB; FungiDB:CPSG_02464; -.
DR VEuPathDB; FungiDB:D8B26_003033; -.
DR eggNOG; KOG2519; Eukaryota.
DR HOGENOM; CLU_007575_0_1_1; -.
DR OMA; VPRCGPK; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR CDD; cd09906; H3TH_YEN1; 1.
DR CDD; cd09870; PIN_YEN1; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041177; GEN1_C.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR InterPro; IPR037316; Yen1_H3TH.
DR PANTHER; PTHR11081:SF71; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF18380; GEN1_C; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
FT DOMAIN 58..157
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 167..246
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 549..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 92829 MW; ADAABB178C0C0B21 CRC64;
MAEYAPSQLA AACLITGCMQ NTQFITGPNG FPVTMSLISI HGYSRVSMFI SVVLGTNIAF
SLLQELGPGD RVSLAKLAID HFQQTSRPLR IAIDVSIWLF QAQAAQGGLN PELRALFYRL
ARLISLPVHP IFVFDGSGRP EYKRGKLVIR NGRSGAWNIR SSKRLIELFG FHHHDAPGEA
EAECAKLQTM GIVDAAMSND IDTVMFGSKI TFMNFSRASK GPSAATHVSV YRRDGSAANV
PFDVGGMALF ALLSGGDYLP AGVPRCGPKL AAEIARAGFG TDLLDIITSN PRDLTTPLNE
WRKRLDYELS TNESGYFKSK HMAVRIPESF PDLQVLFDYI HPLTSSERDL EKLRNLQWNR
DFDVSALRQF VSEELGWKSL AGAHRFVRKL APALICYHLY AQPQDPPRAK VSGRKDNTTM
DGLAEIKLQF VPAQVVGLNL ELESESLSQT ESADVTVDMV ESDDEDDGIE MLHSTTQRVF
YDPTKEQTLW VFEALVKVGM PDAIQQWQDE QERKKLAASK PQVSKKGARG TKKVVDAGMA
PGALHRYGTI VKPQLRTSTA LGKSGRSTIE RRNQTGEGRR DSMSNHTQRT IADCTAFAVR
STKSGTSSFS REPKPARKVD HPTSSDIEAA MALGDSDEGR LPCSTNPKDD SNHSHSLRAL
DLLETEFQSI TISSSSDEGS SRAERRGKAS PVKGRSKASK SRETRNKLGP SKFNTTHLSP
QASVSSSDTS LIKEARATPK QSAQPILKPP CEGKNLKSLD SLLVDDFQGL SIQDENSLQS
TEAPSEQTTH IHLQDINIWN GFWTHTPGVR SKDTSLANYC DKAPTQSKSS KQKKHAGRIS
ILDLT
//
