ID E9DDG7_COCPS Unreviewed; 2676 AA.
AC E9DDG7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Translation activator GCN1 {ECO:0000313|EMBL:EFW15692.1};
GN ORFNames=CPSG_08129 {ECO:0000313|EMBL:EFW15692.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR EMBL; GL636500; EFW15692.1; -; Genomic_DNA.
DR STRING; 443226.E9DDG7; -.
DR VEuPathDB; FungiDB:CPSG_08129; -.
DR VEuPathDB; FungiDB:D8B26_008399; -.
DR eggNOG; KOG1242; Eukaryota.
DR eggNOG; KOG1696; Eukaryota.
DR HOGENOM; CLU_000504_1_1_1; -.
DR OMA; KYATQRG; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022716; Gcn1_N.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF12074; Gcn1_N; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1350..1583
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1524..1562
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1984..2021
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 2638..2660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2676 AA; 292810 MW; 87D482BB8CB024B1 CRC64;
MDEIKWNNVH DGMLESLKPV IFSGSTSRRR AGLHELHEKI LSHELPKELD RPLLDLLFGT
YPIYVDRDSR RDAQRCIRDI FQAPIASVDL KDFANKLHKE CYKPAIAAAN AFVLIEWCTL
LLQHLSQREA ENPEDAPQLA VNVLSANSKA LETCLRSSKK EGLKHSAIIV SRRALRTVLS
KEETGDEVVR RLVRVLTSET GSGFRNAPYL GVLSGVCARL PKRRAVLDDV KPAIFQFYIK
DIIGSRTVVP SHIAGSLGDF FISFASAEDL QKEIWPSLEK AMLRSPEVVF TGIIPSFVAA
IPREIELSEV VSTRLSKPLL SSFKSASQTV RQGAVKAFEA LIAKCKEEQW LLKIIDEVIL
PLKTSRITNV EHRALQVQVL SIFHCFPELS HRVLSGLSPA LARESNEAAL ESEVQAFCHH
LAYLIRSQST ISKEDFSVVA KGCAEKRSAF RKIWISNVGE VIWNLDRDSL FSSSSVKTNF
LKPVVEKISS SFDEINANPL PAVQGGTISI AYVLLALSCQ NLQGGKLDDG SLLLNTDVIV
GQSLSLSLKQ SFLLNPRIFT KLASKDELAW NIRALSGVSS EAAFQAVDPT VRDTWAQAFI
YVISSAATPE NLRESAISHL RNCYLKNPQV VGMAIISAMW KWLLAVNTGD KDSAALSAGT
GGDKLLLVVR AITPSPNVVD SLVLDRQLIE LLVLCRPELI PRANWIEITL RAGADPGKIA
QSYPKECIAQ VLLATEDPIR SKLSKGRTAA WNAAADLAFV APDVMMPILV KQIQEDLNID
RITRFGPTDI AIARHSGETP FIDVLSTKTK RLPGKGDKDY DTLKWEAELR AEMAQKRGQH
QKKLTPEEQV KVKAQLLKEA EIRKSIQIQE QIIRRGAGIV ESLARGPATE AEEWINQAVN
CLCRLVEVDA GALVGSSISE AYVACTSRIS SRLEEIRPFI GIATLRSLGK TYMPSDLEVE
PLGTLVTRIL YRIRLASEQR PFDVVSFGIM LRLIIVVLEK DGVKEAAESR GEQILLALEF
LTIHANLFSD SRLPRTEVLR TLISAMRIHA EHYKLMRDLL IDICRSVTDN VQPDELTILL
QGVIVPETSV RTAVLQAIEA EIDLTDLDFS EYIWLGCHDH VSENAEISKA IWEENGLEVD
ANSPDFIMEY LGTADSQLRG AAAVALAHAC KFSPSVFTTT LEKLETKYQD EIKPRAPETD
AYGMPKKVDT PDNWQLRSGI ALALKSMAQG FHGDQIVGFL QFLISEGPLV DQNVSVRRQM
AESGSAVIAL HGQDNVEELM HLFEKTLETS DKATEQSDWL NEAVIILYGS LARHLKSGDK
RLQTVIKKLL AALSTPSESV QYAVSECLTP LIRLSPIETS VYIDELVDQL LHSKRYATRR
GAAYGLAGIV HGRGISALRE FRIMPRLKEA SENKKDPNER QGSLLAFELL SLVLGRMFEP
YIIQILPQLL TAFGDPSVDV RDACLDTAKA CFASLSSYGV KQILPTLLEG LDDPQWRSKK
GACDLLGAMA YLDPQQLAVS LPDIIPPLTV VLNDSHKEVR NSANRSLQRF GDVISNPEVK
GLVNILLKAL SDPTKYTDEA LDALIKISFI HYLDAPSLAL IVRILERGLG DRSTTKRKAA
QIIGSLAHLT ERKDLTSHLP ILVAGLKIAI VDPVPTTRAT ASKALGSLIE KLGEEALPDL
IPSLMTTLKS DTGAGDRLGS AQALSEVLAG LGTSRLEETL PSILQNVSSA KSAVREGFMS
LFIFLPACFG NSFASYLNRI IPPILSGLAD DVEAIRETSL RAGRLLVKNF ATKSIDLLLP
ELERGLADDS HRIRLSSVEL VGDLLFNLTG INTKADIEEE DDTAAQAGQS LLEVLGEDKR
NKVLSALYIC RCDTSGLVRS AAINVWKALV ASPRTLKELV PTLTQLIIRR LGSANMEQKV
IAGNALGELI KKAGEGVLST LLPSLEEGLL ASTEVDARQG ICIALRELVI SSSGESLEVY
EKILISTVRT ALLDSNQDVR EAAAEAFDAL QQALGRRIVD RVLPDLLNLL HTDAEADRAL
AALLTLLTET TRANIILPNL IPSLLASPMT SFNAKALASL AEVTGGALTR RLPNILNTLI
DNSLSTKNEK LRPEINSAFD TVLNSVDECD GLNAAMNVMI TLMKHEDHHK RAAAANRLSS
FFGKTTLDIS RYYPELVRVC LISFDDYDTN VVAAAWEALS QLTSHMRKEE MEVLVIPTRQ
VLRQVGVAGA NLPGFCRPKG ISAVFPIFLQ GLLNGTVEQR VQSALAIGDI IDRTSTEALK
PFVTQITGPL IRVVSERSVE IKCAVFLAIN KLLEKIPLFI KPFLPQLQRI FARGLADSSS
ETLRSRAAKG LGILITLTPR VDPLISELVA GSKTSDSGVK SAMLRALHEV VAKAGKNMSD
ASKQAILELI DDESADRDEA TNIANAQLVG ALIKSLPEAT AVPLIKNRVL TSHYTHLSVL
ALNSILAESP RSITDTFPDE TLSTICEGIK HKDVFIADNS VLAAGKYLLT TDIDRDAETD
RVVLEALTSV IPPGNPADTR RVALVVLRTV SRLEPGLVGP HLSLLIPPVF SSVRDLVIPI
KLGAEATFLA LLQVVDAGSV IFDTYLQGPG AGLPMTTKRS MQDYFKRVAL RLATQARERR
DAEGGAGGLD LASDEADDEK ELWSVGKVDL GDFSED
//
