ID E9E0P8_METAQ Unreviewed; 1070 AA.
AC E9E0P8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Sulfite reductase [NADPH] flavoprotein component {ECO:0000313|EMBL:EFY90452.1};
GN ORFNames=MAC_03446 {ECO:0000313|EMBL:EFY90452.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY90452.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY90452.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; GL698490; EFY90452.1; -; Genomic_DNA.
DR RefSeq; XP_007809786.1; XM_007811595.1.
DR AlphaFoldDB; E9E0P8; -.
DR STRING; 655827.E9E0P8; -.
DR GeneID; 19247757; -.
DR KEGG; maw:MAC_03446; -.
DR eggNOG; KOG1158; Eukaryota.
DR HOGENOM; CLU_003662_1_0_1; -.
DR InParanoid; E9E0P8; -.
DR OMA; MIVAVNW; -.
DR OrthoDB; 5488444at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR CDD; cd06207; CyPoR_like; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR19384:SF109; SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01558; POR; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 683..914
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 1070 AA; 117575 MW; F799F312B932B031 CRC64;
MRSQPQESTG GAVIPQKTDS SDFVILSSAL PFGQPVPLDA ISGTTYVTAQ LLVQQIAYKL
SDKIFSYSPE TFDLDIAAKD WAAKQNTNIH GYAPQVFPLQ TRTGAGALAL GYIFSPDFDV
SKRHIPQTLL APSGSLQQLR GALDQLSLLY SVSSPFVAHV AAADYTDADG LVSNYDTALR
LAEDLGLGLV SSSSTYEAQH MSLFSTLLAT VLPTLHVYDG IRVARETLRV VDALSESGIA
DVYNKLVSEA GKLNSHLDIA GKVLELLKLF NDELGTVYQP FEYHGHEAPD VVLVAFGSVE
TQVAKQTLNK IAADGAKVGV INVRVYRPFI EEEFLNAIPA STRTIAVLGQ VRDHVAVADH
ATQSALYGDV LAAVTFSGKF EEEPRVLDIK YAPAQSLTPQ GLVNTLHKVF GNEDEARALP
SLVNAEQYTF WDVDNSAAAN SPAIIGHILS KQSTTNVYVH ATYDNLTQGG VVRTDVRASR
KALEAPYDVY EADVAVIGDD RVLKDVNVVE SVAHGGKMIL KLPNFKVEEV EKRLSAAFRK
AVQEKDVQLF VLDTSFSPAF EKDSQSKLLL ELAFLKVAQP ELSPETLSKL VLVEGHPPTL
EECVEAVNQC LSKLEVPAAW AEVADNFEVP QLPISLQSNS FVPFQKQEAE EALELRDWQT
AAKGLVFKEV YETRTGLRPD LPVKTATIRV KENRRLTPSD YDRNIFHIEF DLGNSGLTYK
IGEALGIHAE NDEEQVSAFI QAYGLNPAEL ARVPAREDPE ALEIRTVHQA LVQNVDILGK
PPKRFYEALA EFATDETERK KLEALGSSAG AEDFKRRSEV DMLTYVDVLD EFKSARPSFN
DLVKMVSPLK RREYSIASAQ AVTPNSVTLM IVVVDWVDTK GRTRYGHATR YLSRLQPGAV
VTASVKPSVM KLPTRDTAPL IMAGLGTGLA PFRAFVQYRA MQKAQGKEIG AILLYLGSRH
QREEYLYGEE WEAYLAAGVV TLIGAAFSRD QPQKIYIQDR MRQTLGDIAK AYVQDQGSFY
LCGPTWPVPD VTKVLEEAIA ADAKASGKKV DPKKEIEKLK EEGRYVLEVY
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