ID E9E2R5_METAQ Unreviewed; 352 AA.
AC E9E2R5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Homocitrate synthase {ECO:0000313|EMBL:EFY89731.1};
GN ORFNames=MAC_04163 {ECO:0000313|EMBL:EFY89731.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY89731.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY89731.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698496; EFY89731.1; -; Genomic_DNA.
DR RefSeq; XP_007810503.1; XM_007812312.1.
DR AlphaFoldDB; E9E2R5; -.
DR STRING; 655827.E9E2R5; -.
DR GeneID; 19248474; -.
DR KEGG; maw:MAC_04163; -.
DR eggNOG; KOG2367; Eukaryota.
DR HOGENOM; CLU_022158_2_0_1; -.
DR InParanoid; E9E2R5; -.
DR OMA; NMFAHES; -.
DR OrthoDB; 2781767at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044283; P:small molecule biosynthetic process; IEA:UniProt.
DR CDD; cd07948; DRE_TIM_HCS; 1.
DR Gene3D; 1.10.238.260; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR048253; DRE_TIM_HCS_fun_bact.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR10277:SF48; HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED; 1.
DR PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 137..248
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 38616 MW; 4226C80866C731FA CRC64;
MCGDRSAVNG TNGTNGTANT IRNRTPYESV GDFLSNLQNF KIQSREDCEA ICKLGLKAKI
LTHVRCTMED ARIACDTGVD GVDLVIGTSS FLREHSHGKD MVAIEKAAIE VINYVKSRGV
EVRFSSEDSF RSDLVDLLQL YRAVDRIGVN RVGVADTVGC ATPRQVYDLV RTLRGVVSCD
IEVHLHNDTG CAIANSHAAL EAGATHIDTS VLGIGERNGI TSLGGLMARM MVGSREYVMS
RYKLHKIKEI EDMVADAVQI AGIHAKAILA NPSTYEILSP EDYGLSRYVH FASRLTGWNA
IKSRVEQLGL SMSDEQVKEV TAKIKQMADI RPLAIDDTDS IIRSYHLELQ QQ
//
