ID E9E363_METAQ Unreviewed; 683 AA.
AC E9E363;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|RuleBase:RU364059};
GN ORFNames=MAC_04311 {ECO:0000313|EMBL:EFY89658.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY89658.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY89658.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
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DR EMBL; GL698497; EFY89658.1; -; Genomic_DNA.
DR RefSeq; XP_007810651.1; XM_007812460.1.
DR AlphaFoldDB; E9E363; -.
DR STRING; 655827.E9E363; -.
DR GeneID; 19248622; -.
DR KEGG; maw:MAC_04311; -.
DR eggNOG; ENOG502RYK5; Eukaryota.
DR HOGENOM; CLU_008378_1_0_1; -.
DR InParanoid; E9E363; -.
DR OMA; KWAEWIR; -.
DR OrthoDB; 2102567at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR35041; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR35041:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 120..550
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75213 MW; 40EB1293CAA51BB0 CRC64;
MATPTPMKHA PSQQGRTPSQ LAAATPPVST PFSNTARAAF SPRGPGSSPQ QVKKSPATST
LMGHTGMGAF NFDSPSTAAA MGALGMGGGF DIGLDNVGVG GLDAIGAALA NEDDKMKRLD
TILTLLSAKK GLVSEASLER LAQRIGLELL SEEQRTPDGR KTRTLAIAGS AIALDIVLDN
NIVQSVSLAY HGSASSVSKH MDAAGRILLK DLKLLPGQSP LTKTLENFAS NFERLASLDK
LSIVPGLDCH EALAGIYVSL ERLYQWDLSN LREEQDMKAK SDKYLSNMVM CSMHGRPVMH
DRDTVGLAIQ YWRELRFMPP VADGVYTYDY ESDKVWSLLL GCAPLDGMGV PPVRVSENWI
SKEITKQDAM IDPTKTILDW QEPDNVSLPQ SEDNKDAGMD LLQADLSTTR VPRVMFTVTF
DPPVVLPQND WARLYMYANV NPPNIVNELG QRGHPPSPPT FDSLLFPFPS GVKVDPSESR
AIVRQRLVRV LKTNRTESVA NHNNTLYIYK PIYSQTVSEM PFSHPRQLLD MLPLLRQYAF
LSTLLENSFG SKTKPAETPT QVRPTHIKTK KDRLAEYMDG PEPDAFSVDH ASDTDLDVIL
WVHPAPHMQV VFPMGNSTAN ISLKILEGGI VEIVDENILD CNDNGEIKGR RKEFTRQKMG
KVLEYMEDLC LWSEWIRSRL GAS
//
