ID   E9E3M9_METAQ            Unreviewed;       538 AA.
AC   E9E3M9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=AIF-like mitochondrial oxidoreductase (Nfrl) {ECO:0000313|EMBL:EFY89454.1};
GN   ORFNames=MAC_04473 {ECO:0000313|EMBL:EFY89454.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY89454.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY89454.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00006442}.
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DR   EMBL; GL698499; EFY89454.1; -; Genomic_DNA.
DR   RefSeq; XP_007810813.1; XM_007812622.1.
DR   AlphaFoldDB; E9E3M9; -.
DR   STRING; 655827.E9E3M9; -.
DR   GeneID; 19248784; -.
DR   KEGG; maw:MAC_04473; -.
DR   eggNOG; KOG1336; Eukaryota.
DR   HOGENOM; CLU_003291_4_2_1; -.
DR   InParanoid; E9E3M9; -.
DR   OMA; RCTHYGA; -.
DR   OrthoDB; 495825at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd03478; Rieske_AIFL_N; 1.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR028202; Reductase_C.
DR   InterPro; IPR017941; Rieske_2Fe-2S.
DR   InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR   PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR   PANTHER; PTHR43557:SF2; RIESKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF14759; Reductase_C; 1.
DR   Pfam; PF00355; Rieske; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR   SUPFAM; SSF50022; ISP domain; 1.
DR   PROSITE; PS51296; RIESKE; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          7..102
FT                   /note="Rieske"
FT                   /evidence="ECO:0000259|PROSITE:PS51296"
SQ   SEQUENCE   538 AA;  57125 MW;  15D153BD0023E54E CRC64;
     MAQEFRLKDL TSLSLSPGSK QEVEVEGVDG GKVLLVNTGG QIRAIGAKCT HYGAPLAKGV
     LAADGRVKCP WHGGSTGDVE EAPALDALPV FKVIERNGAV YVIGDESAIK NSRRQPNLSC
     AGPPTADEKV VIVGGGSGAL GAVEGLREKG FTGGITVISN EGYYPIDRPK LSKALMTDLS
     KLQWRDKSWF ESGNVEWVEG EATAVNFGER KVTTKNGQNI SYTKLILATG GIPRTLPLNG
     FRVLGNIFTL RNVHDVKAIV GAIGDKGKKV VIVGASFIGM EVANAICKDN TVTVADMSKV
     PLERVLGEKV GAGIQKAVES KGVKFHLGGG IERAEPSPSN PSKVGAVILQ DGTKLEADLV
     ILGVGVMPAT DYLRDNPVLR LEKDGSVQTD ENFQVSGLKD VYAIGDIATH PYSGPGGEGK
     LVRIEHWNVA QNSGRHVANH IVNPTQNRPL NIPIFWSALG AQMRYCGNTA NGWDDVVVDG
     DPAEAKFVAY YTKGETVVAM ASMGRDPLMS QSAELMRLNK MPSKKHIQDG VDVLSIAA
//