ID   E9E7W3_METAQ            Unreviewed;       932 AA.
AC   E9E7W3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=ATP dependent DNA ligase domain protein {ECO:0000313|EMBL:EFY87970.1};
GN   ORFNames=MAC_05961 {ECO:0000313|EMBL:EFY87970.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY87970.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87970.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572}.
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DR   EMBL; GL698518; EFY87970.1; -; Genomic_DNA.
DR   RefSeq; XP_007812301.1; XM_007814110.1.
DR   AlphaFoldDB; E9E7W3; -.
DR   STRING; 655827.E9E7W3; -.
DR   GeneID; 19250272; -.
DR   KEGG; maw:MAC_05961; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   HOGENOM; CLU_004299_4_0_1; -.
DR   InParanoid; E9E7W3; -.
DR   OMA; RIDEFWR; -.
DR   OrthoDB; 2788069at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR45997:SF2; ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430); 1.
DR   PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EFY87970.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          343..483
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          638..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..695
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   932 AA;  103506 MW;  212E3D32ADB90FDB CRC64;
     MPIPFVLVCD LLDECHRLCI ANKPNTQAVV DWFARHRGRI NAHDTDPAAL LSTLLPEKRT
     DRVYCIKAPT LEKIIGRALM LGSSRIVELA LYKQPGQRTD LADCAERILN TTPNPTSNEK
     PRISVEEIDE ALHRLASRIK WSSPSIRNSQ AALTPRGRCD LEDFYRRLTP REAKWFTRLV
     LKDYQPLILD SELVYRCCDS TLPLILKAQD DFATAIQTLQ SAKGNMLPNS TRSTSRRDQI
     LAAVKPKLGV KVGRQNWFKG RSIKHCLDMG HGRMSVEQKI DGEYCQIHVD LTSGNSRVQI
     FSKSGKDSTE DRHKLHGNHV TRRGRLMDVD LDSPPRSYEN LMIVYYDILF HDDRSLLGVR
     HSERFKILQK TINCEGGRAE LVKRTLVDFD RPTAASELRK AFASVITDKG EGLVLKPDDP
     YFNFQAKDGR SSGLCIKLKK EYIGNFGDVG DFAVVGAGFN PTKASSYRIP NLQWTIFFVG
     CLNNKEEVKR WNAKPEFTVV SAVEITEPLL RNFISHCSPV SVPLRKNDAT KLHIPKGIEA
     NASLTAAFQN PAVFDLRCFS FDKPGNVGFW TLRFPAVSKI HFDRDYSDAV TFDELQQMAQ
     VARATPDLED SQENLHWIAK LEGADPRGRA VDAVSQLTAT TMPTPSPSSS RPPLSPIMQR
     PQSRSPEVVR AYGMSQKSAD MSTASLTTPP TSSPVEEEAR TPGRGSKRKC PTSFSPTAAL
     TLQRRLSMTT HSSPVAATKK LRKPLDDVDA NVLQQSATPN SSFEDGGIDQ CVGLTKSPPF
     IQETQENEAP STPDEGINPT KGDIRCTPIT ISSDEASQAT DISPQVKNGC KFAAKECHLF
     KHTILLASRA LGPSSERTTL LGDHGASEFA ISLDDWLQEN NYGATLGKKS SHIIILVDTV
     DKASETKLVL AEVERARKEL PPKTRASQDH GR
//