ID   E9E8D0_METAQ            Unreviewed;       916 AA.
AC   E9E8D0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Subtilisin-like protease {ECO:0000313|EMBL:EFY87880.1};
GN   ORFNames=MAC_06128 {ECO:0000313|EMBL:EFY87880.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY87880.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87880.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; GL698520; EFY87880.1; -; Genomic_DNA.
DR   RefSeq; XP_007812468.1; XM_007814277.1.
DR   AlphaFoldDB; E9E8D0; -.
DR   GeneID; 19250439; -.
DR   KEGG; maw:MAC_06128; -.
DR   eggNOG; KOG4266; Eukaryota.
DR   HOGENOM; CLU_003559_3_1_1; -.
DR   InParanoid; E9E8D0; -.
DR   OMA; FNHPALG; -.
DR   OrthoDB; 662485at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07489; Peptidases_S8_5; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR   Gene3D; 2.60.40.1710; Subtilisin-like superfamily; 1.
DR   InterPro; IPR010435; Fn3_5.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034187; Peptidases_S8_5.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF06280; fn3_5; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..916
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003235539"
FT   DOMAIN          166..583
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   DOMAIN          627..742
FT                   /note="Fn3-like"
FT                   /evidence="ECO:0000259|Pfam:PF06280"
FT   ACT_SITE        175
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        214
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        550
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   916 AA;  97661 MW;  2A097A97D987D7E7 CRC64;
     MHAMVTFLLA VAALAATPSA ANKTPSRVIP GTYFIELHED ADVAGFAHRV KREANARVRR
     QIDYVPDKAK ATAPYKALSI EINDAGKINV VASMEGVVKI HPVEMHSLGG IAPPSDRAKG
     EKQRSFVGKL SKRQATRRAL PETNTTAYPP HVMMQVDKLR SKGITGKGIK IAMIDTGVDY
     EHPALGGCFG PGCLFSFGAD LVNNEPTPKD CNGHGTNAAG IIGARPNPMG FTGAAPGAQL
     GMYRITCSGE FPSDVMVDAI YRALEEGVDI ISSSAGLPGG WPGSLLSSAA TRVVESGVVF
     VQGAGNDGEL GLFSQLDPAV GSGVISVGSV HSRVSPELVV EAKYTIGNGS EVPFLFYPTA
     PSDNFTGTPM EVYALPVNGS GAGNDTHACG PIRDDIPDLS DKLVLLHFRL SPGDCNLWTR
     VKLVHEKGAT RILAYMASED WTPGLYYLDD FPEGVVGLGM LEFNSAKSML KALEAGRKVL
     ATAFPYDDAP LVYVETPNEK VAGSVSSFSS WGPSWNLGLK PSLTAVGERI ITTSPRDQYI
     SGYEITQGTS FSGPLIAAIV ALIGEARGSL DAATIESLLV SHSHPQLYHN RHGFLSYLAP
     VAQQGGGLAR AYDAAYATTL VQPASLSFND TEHMHTAAPF SFTIKNMGAG VVTYRLSHVP
     AVTVYTFTQN GTISSYPNKL DTLEVPATIT LSDTTVTVAP GNSVNIRVSA SAPKSLDPSR
     MPLWSGWIAI NGSDSSSLSV PYQGFSGSIR KHQVLPPDGA TLVYRNVSVS EGTTVVLPTP
     GSITTSQLML NINATLGTPL VRAEVVPLNS TANATNIATK PIGQLQGFPV QWRPSNLQQS
     PDLLQFTQFK WNGQLDTGSN VPEGYYKLVV RALRIFGNPS NDEDWDISES PRFQITYCQK
     RNSSTTVRRR AEKGYN
//