ID   E9E914_METAQ            Unreviewed;       304 AA.
AC   E9E914;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Thiamine pyrophosphate enzyme TPP-binding domain-containing protein {ECO:0000259|Pfam:PF02775};
GN   ORFNames=MAC_06362 {ECO:0000313|EMBL:EFY87650.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY87650.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87650.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812}.
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DR   EMBL; GL698524; EFY87650.1; -; Genomic_DNA.
DR   RefSeq; XP_007812702.1; XM_007814511.1.
DR   AlphaFoldDB; E9E914; -.
DR   STRING; 655827.E9E914; -.
DR   GeneID; 19250673; -.
DR   KEGG; maw:MAC_06362; -.
DR   eggNOG; KOG1185; Eukaryota.
DR   HOGENOM; CLU_915518_0_0_1; -.
DR   InParanoid; E9E914; -.
DR   OrthoDB; 2291769at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF164; PYRUVATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          218..301
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   304 AA;  33030 MW;  9FA8A1EEAF637C67 CRC64;
     MDGEHRGSRT EYIHWIQDVP DQKHIVAQYC RYAGEVKTGA NVKQMVNRAL QFAKSAPQGP
     VYLCGAREIM EADIGPYRLK QEDWEPVRLG GLAESGVARI GNCRRRLRRS LGPDAVQAQG
     RRGRVPRRRR PVEAAHAHVI TAALRTGDAA AKLQAADGRE HAGRVQAEHK QLLASIQDKA
     EPRPDGSFGT GHLCRTLKSL CPEDTIYAVE AVTNASFVHD NIQPTFPGSW INCGGGGLGW
     SGGAALGIKL ATEAESPPGR GKFVVQIVGD GTYLFSVPGS VYWISKRYNI PVLTIVLDNK
     GNHG
//