ID E9EDA1_METAQ Unreviewed; 1196 AA.
AC E9EDA1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=ATP-dependent RNA helicase DHX8 {ECO:0000313|EMBL:EFY86115.1};
GN ORFNames=MAC_07849 {ECO:0000313|EMBL:EFY86115.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY86115.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY86115.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL698556; EFY86115.1; -; Genomic_DNA.
DR RefSeq; XP_007814189.1; XM_007815998.1.
DR AlphaFoldDB; E9EDA1; -.
DR STRING; 655827.E9EDA1; -.
DR GeneID; 19252160; -.
DR KEGG; maw:MAC_07849; -.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_2_3_1; -.
DR InParanoid; E9EDA1; -.
DR OMA; DPMVAPE; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EFY86115.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 229..300
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 541..704
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 722..902
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 134..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 134455 MW; B351C72F8CFBBDA4 CRC64;
MDDLLNLELL SLVSKVTSEL QNHIGISDKT LAEFLISQRL ESSSTDDFRK RLDKIGADFP
PSLVDSLDRL VLAMHPKFKG KGDQINGEEH HSRTLEEKEK VFSGLALADK AVEYDSGADA
IDDTLALLEG LEGKAKKEKV SRKRSRSPEY DGKESRRRRR DRSRSRDRRA RERLRSRSKS
QDRGDEDWRD GFKDSRKDRR GRRRYDEDES DDRFRKAPYP EIDDAPKLNK VYQGHVTGVR
DFGAFVNIHH VRGKVDGLVH ISRIIAGQRV NHPSDLLSKG QDVWVKVTSI EGNRIGLSMK
DVDQETGMDL EPQARLTTGA NMEALGGGVK NGFVNDTSAM PRDALGPPRR HKKRMTSPER
WEIRQLIASG VAKASDYPDL EEDYNATLQG DGEMALEEDV DIEVREEEPP FLVGQTKQSL
ELSPIRVVKA PDGSMNRAAM SGTSIAKERK ELKQQEADAA AKEKQSNQNL SSQWQDPMAD
PDRRTFASDL RNARMQAESE DVPEWKKAVI PKGQSLGKRT NLSIKEQRES LPVYAFRSQF
IEAVQENQIL IVVGETGSGK TTQLTQYLAE AGFADKGIIG CTQPRRVAAM SVAKRVAEEV
GCKMGEEVGY LVRFDDCTSP STRIKYMTDG MLQREILMDS DLKRYSCIML DEAHERTIAT
DVLFALLKKA AVRRPDLKII VTSATLDADK FSSYFHECPI FTIPGRTFPV EILYSREPES
DYLDAALVTV MQIHLTEPKG DILLFLTGKE EIDTACEILY ERMKALGPSV PELLILPVYA
SLPAEMQSKI FDPAPPGARK VVIATNIAET SITIDEIYYV IDPGFVKQSA YDPKLGMDSL
VVTPVSQAQA NQRAGRAGRT GPGKCFRLYT EAAYQSEMLP TTIPEIQRQN LSHTILMLKA
MGINDLLHFD FMDPPPVNTM LTALEELYAL SALDDEGLLT RLGRKMADFP MDPASAKVLL
SAVDHQCSEE ALSIIAMLSL QGAVFYRPKE KQTQADQKKA KFHDPHGDHL TLLNVYNSWK
QNGYSNPWCF ENFIQARSMR RAKDVRDQLV KIMERYKHPI VSCGRNTDKV RRAMCSGFFR
NAARKDPQEG YKTLTEGTPV YLHPSSALFG KQAEWVIYHD LVLTTKEYMH CTSSIEPKWL
VEAAPTFFKV APSDRLSKRK QAERIQPLYN KFAGEDDWRL SAQRRGGRGG GGGTWG
//