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Database: UniProt
Entry: E9EIL3_METAQ
LinkDB: E9EIL3_METAQ
Original site: E9EIL3_METAQ 
ID   E9EIL3_METAQ            Unreviewed;      2571 AA.
AC   E9EIL3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Polyketide synthase, putative {ECO:0000313|EMBL:EFY84249.1};
GN   ORFNames=MAC_09711 {ECO:0000313|EMBL:EFY84249.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY84249.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY84249.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
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DR   EMBL; GL698644; EFY84249.1; -; Genomic_DNA.
DR   RefSeq; XP_007816051.1; XM_007817860.1.
DR   STRING; 655827.E9EIL3; -.
DR   GeneID; 19254022; -.
DR   KEGG; maw:MAC_09711; -.
DR   eggNOG; KOG1202; Eukaryota.
DR   HOGENOM; CLU_000022_6_2_1; -.
DR   InParanoid; E9EIL3; -.
DR   OMA; WHVYARH; -.
DR   OrthoDB; 5396558at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR032088; SAT.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF14; ITERATIVE POLYKETIDE SYNTHASE AFOE-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   Pfam; PF18558; HTH_51; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF16073; SAT; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          434..858
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1697..1771
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1656..1700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1781..1822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1656..1688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1795..1812
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2571 AA;  280879 MW;  277CFDFF8F022F8D CRC64;
     MGGMAYLKPQ EATMLLFGPQ AFSSSKLLEK IRNTLSSDSS EKQCILDTVA ELPQHWSSLI
     ERIPRINGVV PGEKHLADLA SWLQQGPLDE YKLERLPNLV LTPLVILAQL TAYWRYLEIN
     KPEKATSGAE NDLQANLVSK RNSRDGSPLQ TIGFCTGLLS AFAVASAKDQ ADLEKYGAVA
     VRLAMLVGGL VDAQEAWNVE FGQGPSKSYA TAWHNAQERQ ELNRITDSLF PQAYISVLYD
     ESRATVTITQ QAVPAFLQAT KDSGITVAEV GLRGRFHSPS KDFLTLTDTL VELCNSTTLL
     RFPSSSELAL PTYTNDVVDG RPVGSTTDVK GLTLTEIALR AILVKRCNWY STLAAVQANL
     RNDVAFLSFG PDRCVPPTLA RQLGSRLVEF YDLDLDGEVP QHLSSVLDPD AHLLHQQQSQ
     SQPQPQTQPR DESDNAIAVV GMSIKVAGAD DLDEFSQMLR IGKSQHEEIT SERLMMDTLF
     REGDKDPKRK WYGNFIRDVD AFDHKFFKRG PREALTMDPQ QRLFLQASYQ AVEQSGYFAE
     TTSSSPVRDK NHVGVYLGAC AGDYEHHAAG HTANAFTATG NLKSFIPGKV SHYFGWTGPS
     MTFDTACSAS AVAIHTACRN LLSGECTAAL AGGVSTITNF LWHQNLAGAS FLSPTGQCKA
     FDDAADGYCR AEAIACVFLK KASDALADGN TTLGYIPSTA VYQNQNCTPL FVPNSLSLSQ
     LFTDVIKKAH ITPYDVSVVE AHGTGAPVGD PAEYESVLQA LAGPTRSKPL VLGSVKGHVG
     HSEGASGVVS LIKIIMMMQE GYIPPQASFT KMSHYIKTSP TDMMEVSTSL RPWNEERKIA
     LINNYGASGS NASMIVSQSH YNSSGQASSF IRGSGVNNAP FPFLITGFDA RSITAYTAKL
     LAFLKAREKT SVSLADVSFS VNRQSNRTLQ YGMMFSCHSM SELEEKLSMP DKSVAPVQAV
     RPVVLCFGGQ VSTFVGLDQN IYRSISVLRH HLDQCDAIMR SLGLSSILPD IFSRSSITDP
     VKLQSMLFAL QYSCAKSWMD SGLEGKIVSV VGHSFGEITA LCVSGVLSLL DAAKLVVSRA
     KLIRDDWGPD PGAMIAVEAD EETVYKLLAE ANRRYEGEYP ASIACYNGPR SFTLAGSTRA
     IDAVAETIPQ LGSIKSKRLN VTNAFHSTLV GPLMSRLEEP RTTLQLSGSK LDQPPLSHMA
     SRALAGMVKP DAHHFQALSL TNTEKGIHGL TDATLSLWKQ GLRVSFWGHH PLQTTEYATL
     LLPPYQFDKV RHWMELKSPL KAITEAAAAM AATAGPVVIQ PQQSVDERLL GLWSLTAYEQ
     NESPKKARFR INTGSDKYKK YISGHLIAQT APICPATLQV DMAIESLFSL NPHWTASSMQ
     PVVLDMSDHS PLCVDPTKTT WLEFDSLNDS ASVWAWKIFS TSSTGSNETH VEAKLHIRSP
     DEAAYQTEFG RFERLVTHSQ CTAVLNLPDD DDVDILQGRN VYPAFSDVVD YGELYRGVRR
     VVGRAGECAG RVVTKHNGES WLDVPLSDSF SQVGGLYINC MTDRPASDMF IATGCEMAMR
     SPRMARLGKD EVPGSWHVLT RHHRQGEKVY TSDVFVFNAT TGMLTELMIG ITFARVAKAS
     MSKMLTRLTG DESVLKIKPS QAQAALTTTV AAPVPFHPTQ QPQVLDKSAT ETSASQKTSS
     QKKGTESGVS AVKPSRPDVT NDLRNLVANI SGVEPHEIEL DTEMAELGID SLMGMEVARE
     VESVFKCTLD QTELMEATSL RKFVVCLNNA LYGPGYDNAA DESVGTDKDD DFSSQGASDN
     TPTGTGATTP SVPDIKPNAI HDVPSVKPAA TATVAPPVET SLKIASSAIL KAFGDVKMFT
     DQEIRSFKLD RIHRAVLAGS NRLCTALVVE QFEKLGCELR AASPGQVLNR VPFQPQHERL
     MEFVYKFLEK DTRLIDIDEF TGQITRTSIP VPRKASGAIF AELLQAFPEF AVANKLTNYA
     GNHLADVLTG KTDGIRVIFG SLEGRDLVQS LYLDHSFNRM QYGQMRDIIQ HLTQMLPRDQ
     GPLKILEVGA GTGGTTCVLA PMLASLGFPV EYTFTDISPS MVANAKRKLN KEYPFMRFAV
     HDIERPPAGE LVGHHLVIGS NAVHATHNLV TSLANVRKAL RPDGFLMMLE MTESAPFIDL
     IFGLLEGWWL FDDGRKQAIV SAEHWERDLH ASGFGHVDWT DGSLPENRYQ KVIIALASGT
     QSERLPCPMP EDACEPAQGL RDVVAHEAEA NRLMSKHIDA FAAPRLLCSG KTQGAILRDG
     HDAVVLVTGA TGSLGSHVVA RFAEEAAVKT VVCVNRKTGT PVTQRQAEAF SSRAKLGLPA
     EEYAWLAHNV TLIVYNAWPM SGTRPVKAFE QQFQALRNLL DLARDIADTR GHDSGFRVGF
     QLVSSIGVVG EAGKARVPED RVPFSATLLW AIARPNRFRT MVVRPGQIAG SRKSGFWKPI
     EHFAFLVKSA QTLRAWPDFD GVLQWTPVDA AAGVLVDLCR VAQLHNAPEP YPVYHVDNPV
     GQPWKEMNLV LADALGIPAE GIVPFRYWVD MVRRSPLPAE TDNPAARLMT F
//
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