ID   E9F1E7_METRA            Unreviewed;       356 AA.
AC   E9F1E7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Hydroxynaphthalene reductase-like protein Arp2 {ECO:0000256|ARBA:ARBA00015194};
GN   ORFNames=MAA_06096 {ECO:0000313|EMBL:EFY98957.1};
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY98957.1, ECO:0000313|Proteomes:UP000002498};
RN   [1] {ECO:0000313|EMBL:EFY98957.1, ECO:0000313|Proteomes:UP000002498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2] {ECO:0000313|EMBL:EFY98957.1, ECO:0000313|Proteomes:UP000002498}
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- FUNCTION: Hydroxynaphthalene reductase-like protein; part of the Pks2
CC       gene cluster that mediates the formation of infectious structures
CC       (appressoria), enabling these fungi to kill insects faster
CC       (PubMed:29958281). The product of the Pks2 gene cluster is different
CC       from the one of Pks1 and has still not been identified
CC       (PubMed:29958281). {ECO:0000256|ARBA:ARBA00002293}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|RuleBase:RU000363}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFY98957.1}.
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DR   EMBL; ADNJ02000002; EFY98957.1; -; Genomic_DNA.
DR   RefSeq; XP_007822285.1; XM_007824094.1.
DR   AlphaFoldDB; E9F1E7; -.
DR   GeneID; 19260382; -.
DR   KEGG; maj:MAA_06096; -.
DR   HOGENOM; CLU_010194_5_2_1; -.
DR   OrthoDB; 6845at2759; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR24322; PKSB; 1.
DR   PANTHER; PTHR24322:SF736; RETINOL DEHYDROGENASE 10; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857}.
SQ   SEQUENCE   356 AA;  38640 MW;  A55F05F4CCC20409 CRC64;
     MSLVKLSESA PVRGLQSLSA VIQSPYFSGP LLAALLYAPD HLKQQVLQHL PPNFNIDVAK
     NVLQVLLGLG VLKTINQGLS SMAANSWRVT AAKGWDWPSE IAVVTGGCSG IGYCIVKRLV
     ARRVKVAILD VQDPPKDFAA DPLVRYYKCD ITSPDSVAKA ADAIRKDLGH PSILVNNAGI
     TRPLPILEMP QDFLHKIFDV NCLSHWTLVQ QFLPHMIKVN KGHIMTVASM ASFIALPKGA
     DYSATKAAAL SFHESLAIEL KHVYKADSVL TSVAHPNFVR TPLVQDFGHH LEEGGIRMLT
     PDGVAGVITD QIFRKRGAQL IIPDKQSSLT GIRGWPTWLK VILLDQLGSS SSKVGS
//