ID   E9F1K9_METRA            Unreviewed;      1015 AA.
AC   E9F1K9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=MAA_06490 {ECO:0000313|EMBL:EFY98381.1};
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY98381.1, ECO:0000313|Proteomes:UP000002498};
RN   [1] {ECO:0000313|EMBL:EFY98381.1, ECO:0000313|Proteomes:UP000002498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2] {ECO:0000313|EMBL:EFY98381.1, ECO:0000313|Proteomes:UP000002498}
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFY98381.1}.
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DR   EMBL; ADNJ02000006; EFY98381.1; -; Genomic_DNA.
DR   RefSeq; XP_007822679.1; XM_007824488.1.
DR   AlphaFoldDB; E9F1K9; -.
DR   GeneID; 19260776; -.
DR   KEGG; maj:MAA_06490; -.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          393..469
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   DOMAIN          867..945
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1015 AA;  112220 MW;  20F2F15A2315D51E CRC64;
     MNGTTASARG KRKTQISPEN SPPAKRIING KLSPGDNTPD VAEIVQYDGE SESDDIHTSA
     PIYIGTPGSL SEWQDTIQNV VRNVVAIRFC QTCSFDTDPA LTSEATGFVV DSERGYILTN
     RHVVGAGPFW GHCVFDNHEE VDCYPVYRDP VHDFGILRYD PKAIKYMIVD GLDLRPDQAK
     VGVEIRVVGN DAGEKLSILS GVISRLDRNA PEYGEGYSDF NTCYYQANAA ASGGSSGSPV
     VAKDGSAVAL QAGGRSDGAS TDYFLPLDRP LRALRCIQQG NPVTRGDIQC QFLLKPFDEC
     RRLGLQPEWE AEVRKAFPDE TNMLVAEIVL PSGPSDSKIE EGDVLVKVNG ELITQFIRLD
     DILDSNVGES IKFQLQRGGE DIEVEIKVGD LHSITPDRFV SVAGASFHNL SYQQARLYAV
     AVKGVYVCES AGSFRVDNTD NGWIVQTIDH KKVPDLDTFI QVVKAIPDKA RVVVTYKHLR
     DLHTLNTTVV YVDRHWSSKM KQAVRNDKTG LWDFSDLGDP LPPVPPVRRS ASFIELDHMP
     HPGIAELIKS FVHVNCTMPV KLDGFPKNRR WGMGLVIDAE KGLVLISRAI VPYDLCDITV
     TIADSIIVEG KVVFLHPLQN YVIIQYDPAL VDAPVKSARL SSEHLSQGAK TYFLGHNRIG
     RVVHGATTIT EITAVAIPAN TGAPRYRAIN VDAITIDSNL GSTCNSGVLV APDGTVQALW
     LSYLGERSPC TQRDEEYYLG LGTPTLLPVI STIQRGESPR LRLLSVEFRA IQMSQASVMG
     VSDDWIKKVT QANRSHHQLF MVSKRTFERV NQPVSLLEGD IILTLNGKIC TTISDFDVMY
     SNEVLDAVIV RECEEMPLQL ATVPADDIET DHAVSFCGAI LHRPHQAVRQ QIRKLHSEVY
     VSSRIRGSPA YQYGVAPTNF ITHVNKVATP DLDSFIAATR KIPDNTYFRL KAVTFDCVPW
     VITMKKNDHY FPTMEWIKDS NEACGWRRVT YEGKEIFQGE AVDGVLPIAE DTDME
//