ID E9F4U7_METRA Unreviewed; 473 AA.
AC E9F4U7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 22-FEB-2023, entry version 53.
DE SubName: Full=Peptidase aspartic, active site protein {ECO:0000313|EMBL:EFY97279.1};
GN ORFNames=MAA_07296 {ECO:0000313|EMBL:EFY97279.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY97279.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY97279.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY97279.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY97279.1}.
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DR EMBL; ADNJ02000005; EFY97279.1; -; Genomic_DNA.
DR RefSeq; XP_007823485.1; XM_007825294.1.
DR AlphaFoldDB; E9F4U7; -.
DR GeneID; 19261582; -.
DR KEGG; maj:MAA_07296; -.
DR HOGENOM; CLU_047284_0_0_1; -.
DR OrthoDB; 2543989at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF65; ASPARTIC-TYPE ENDOPEPTIDASE; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..473
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003236208"
FT DOMAIN 62..383
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 276
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 312..348
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 473 AA; 51339 MW; AB3BB882E9C8B023 CRC64;
MHFHRASLPL LGALSLSARA APQSEDLTAQ RPGIIQLSLK PPSARDGRQA DIDLTYASNY
KYDIEFSLGT PGQKIVGSFD TGSAHIWVRE KAEASVNTTV ARARSYFDKN SSSTLVRTGG
SATSGYNTAG NSSYQIDLYR DNMSLGGIDI KNASFGIINN APRALDSFNS IFGFGMTDEL
GSEEKEHFVP TMTLLADQGL IDRRVFSLEI GDSSGVLLGG VNRKKFWGRL GKQKMTVHPF
HGKSYVISFT EVSATAEDGS KSSLSRSDEG IPALLDTGAT LNNFPPSVFQ PILKRFPGAK
PMDNRPLYSV DCSLRDVNAS IDLAFGKTTI KMPYRNFVFP TNKKGDLCVL GMMESQEHTV
LGQVFMRGAY IVMDQDNSEV YLANAVTCGS ELVAIDKDVS AISSLTGQCR PPVVEQNLLP
WKKPGIDPEN CVNAISEDVC GTAEYCRIFP GAFGSDFETE DDCLAAHEVP LDD
//