ID E9FRN8_DAPPU Unreviewed; 803 AA.
AC E9FRN8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Pre-rRNA-processing protein TSR1 homolog {ECO:0000256|ARBA:ARBA00040070};
GN ORFNames=DAPPUDRAFT_299992 {ECO:0000313|EMBL:EFX89886.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX89886.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX89886.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC the nucleolus. {ECO:0000256|ARBA:ARBA00037087}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Bms1-like GTPase family. TSR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038288}.
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DR EMBL; GL732523; EFX89886.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FRN8; -.
DR STRING; 6669.E9FRN8; -.
DR EnsemblMetazoa; EFX89886; EFX89886; DAPPUDRAFT_299992.
DR KEGG; dpx:DAPPUDRAFT_299992; -.
DR eggNOG; KOG1980; Eukaryota.
DR HOGENOM; CLU_009858_1_0_1; -.
DR InParanoid; E9FRN8; -.
DR OMA; MNLPRFK; -.
DR PhylomeDB; E9FRN8; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR PANTHER; PTHR12858:SF1; PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG; 1.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 86..261
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..453
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 92151 MW; D68C17E1128AD20A CRC64;
MAGGEQASHR PGLLKQQNKS HKNGRHRSKS EIDKNNKGRV HVKLASKRKN QELKRDERRR
KANQIRSKKR EDVLAKKRAI GGNDSAPFLS AIIPLGESAN IQKLLKQIKE CDADAKVEMT
GSNVININVP RFRQNFSLIV PCPGDLYAAL DACKVVDNVV FLISPPSDTD SCMSHSTTNE
GPLGFDNSGE ELLSAIMAQG LPSPIFVVND IETISLKKRN DYKKLLMKQL DQMVPLEKLQ
VIENESDALR LLHHIGSQKQ RPIYQRNMRC HFLCEEVNFK QNSDDPTVGS LIVDGYVRYQ
PLNVNGLVHI PGWGDFQMER IEVRREPGEF IFLEEANPAI QESLKSENDP DPMNGEQTWP
YQEEMEGQTL EAVKIEDDEE SEKKKRVPKG TSEYQAAWIK DEDDDKNEEN AEEEEEDSDD
WEDDYEDMSG DDGSEESHEE AEEDEMESVD NEGGDTDVYD KKVKFADEEE EFKKIKEARE
DELFPDEVDT PRDTLAKVRF QKYRGLKSFR TSPWDAKENL PMDYSRTFQF QNFPRTRKRI
LKEERTGAKP GWYVRVHVKN VPSHLPASLQ SGYPLTLVGM LPHEQRMSVV NLVLKRFKNA
RDQQAIPSKE RLIFHCGYRR YAAAPIFSQH TAANKHKYER FFRPESVVVA TLYAPIIFPS
ASVLVFREKK DGTQVMIATG SVLSVNPDRI TVKRAVLSGA PFKVHRKSAV LRFMFFNRED
IEWFKPVELR TKYGRRGHIR EPLGTHGHMK CVFDGQIKSQ DTVMMNLYKR VFPKWSYDPN
VASPSPLYNH EVEMEDAANQ LMV
//
