ID E9FS57_DAPPU Unreviewed; 915 AA.
AC E9FS57;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFX90374.1};
GN ORFNames=DAPPUDRAFT_309661 {ECO:0000313|EMBL:EFX90374.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX90374.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX90374.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; GL732523; EFX90374.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FS57; -.
DR STRING; 6669.E9FS57; -.
DR EnsemblMetazoa; EFX90374; EFX90374; DAPPUDRAFT_309661.
DR KEGG; dpx:DAPPUDRAFT_309661; -.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007257_1_1_1; -.
DR InParanoid; E9FS57; -.
DR OMA; MGINIGR; -.
DR PhylomeDB; E9FS57; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0008066; F:glutamate receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..915
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003239718"
FT TRANSMEM 577..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 446..817
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 456..521
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 915 AA; 102708 MW; B3724FFD287D207E CRC64;
MFKLLASIVF AITWISMIQV EPVDALPDVI YLGGLFDTTS DPSLDMAYRY AMKMVQANRQ
ILPRSRLSRV PLGSGNVEFL PPNDSFIASK KVCQMIRFGV AAIIGPQSEA SADHVQSMCQ
TMKIPHIQTH WDPKRLTAMD VMKNGDRNNY AGRNSNSPLS VNLYPNPASV SRAYADVING
WKWKTFTVLY EDEDGLIRLQ ELLQLSISPG YKIIIRQLPD SDDYRPLLKE MKKNGERNIV
LDCSQLSRVS EILQQAQQVG MTTLAQSYFI TSLDMHILDY DQYKQGGANI SGLRMVDPHR
RETVDVLGKW NNWELSAGKN LNVTEKTLTL EAALVYDGVQ LLAKALHDMG RSQEVTPKSF
SCDGIDTWAQ GNNLINFMKT TEIEGLSGTI KFDSEGSRSN FHLSIVELQP DGLTEVGTWN
SIEGPDFFRL RSDGQSLIQE SLFNKTLVVT TILSNPYFMM KESDQILVGN DRFEGFVFDI
IDEISQMLGF NYIFKLVDDS NWGSLNKITG EWNGMIRELL DGKADLAIAD LSINYDRESA
VDFTMPFLNT GISILYKKPQ KKPPNLFSFL SPLSVEVWIY MCTAYLAVSL SIYAMSRITP
YEWNNPHPCR QQPDILENNF TILNAMWFTI GSLMQQGSDV MPRATSTRMV AGLWWFFTLI
MISSYTANLA AFLTVERMDS PISSAEDLAK QTKIKYGSVG SGSTLDFFRY STLPTQQRMW
TFMETTRPSV FVKSTKEGVE RVQRSNGQYA FFMESTSIEF FTERRCDLTQ IGFPMDSKGY
GIAMRPGSPF RAVLSQAVLK MQETNRFIIL KKKWWTEMRG GGACKDDGSK TAASAAELGL
ANVGGIFVVL ILGSSVALLI ALGEFVWKSR KLALDEVDGG EGSVWKSMMS ELKITLDCSS
DTKPTRSTRS LTNNS
//
