ID E9GTG4_DAPPU Unreviewed; 482 AA.
AC E9GTG4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_247979 {ECO:0000313|EMBL:EFX77221.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX77221.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX77221.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GL732564; EFX77221.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GTG4; -.
DR STRING; 6669.E9GTG4; -.
DR EnsemblMetazoa; EFX77221; EFX77221; DAPPUDRAFT_247979.
DR KEGG; dpx:DAPPUDRAFT_247979; -.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_566542_0_0_1; -.
DR InParanoid; E9GTG4; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00181; EGF; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 234..315
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 309..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 206..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 410..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 212..234
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 313..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 331..340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 482 AA; 53882 MW; 889C9B10EBE0538C CRC64;
MASNENDNNN KPRARVWHVW FGSVSYRKIS FAPKTQAEPS QAKQQHDKIT LNVIEKKNHG
LVSCDVACDL ERQSKEFFPM FSDILSESLC PAVLNNEGKT TTVAHSNLLG GNDEEKKVKF
EKFLTVSSSI PAGHCSWFLA RIESGRVGHA MTEDEKQLAF EQLLGKTSRL RMAGSSQTSF
EATTIQPPTI ATMSTAMPIM LSDEEAKRHD RRHAVHQPKK HNKKDHSKRQ HHAGRHVCTH
EETITRPIRV VESYCKPAYK SFTQRCSNGT MCTAFRVQYD TIYRTVVKYQ TTTEKKHACC
PGWTHTEKHT HGCLQGCKNG GTCVKPNTCN CAPGYTGPSC ESGIVGNLST VSNEQKIRLE
LVPELQTLLI NYESMSKRLA ALEQEPRVNS SPSQPHPAPQ VDVIDYQSTI ANMTDHIILL
EEKLNKLQNE TTILIANSNN TVESSNNESL ESLSEQVAIL EERLADCTCT MAPVDNTVKT
RL
//
