ID E9GV66_DAPPU Unreviewed; 1052 AA.
AC E9GV66;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Retinoblastoma-like protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_322171 {ECO:0000313|EMBL:EFX76662.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX76662.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX76662.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; GL732567; EFX76662.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GV66; -.
DR STRING; 6669.E9GV66; -.
DR EnsemblMetazoa; EFX76662; EFX76662; DAPPUDRAFT_322171.
DR KEGG; dpx:DAPPUDRAFT_322171; -.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_008943_0_1_1; -.
DR InParanoid; E9GV66; -.
DR OMA; AILCELH; -.
DR PhylomeDB; E9GV66; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 65..208
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 393..588
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 602..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 119102 MW; 924D9B0DAA1BC50C CRC64;
MGLSEDADQE NTEERFRGLC ADLNIDKNTA DEAWRNYETI STNYTLEGDR IHWLCCALYV
ACRNSTVPTV GQVGTVEGNC VSLTQLRRKC NISMLDFFDK SRKWADMANL SEELRRKFVS
LERNFEVCSV IFKKYDEMFK EIFQDPVNDP PRQPRSRKSR KLPCSAKDVY DFCWAFFVRI
KTNFSQIHEE LVSCFHLLLA CLDYIYGNSL VANRRELFNP QFPGLPSDFH SRDYKAPTEP
GCIVECLYSR NSSQDEKTVV DVKRIKTHVL RPYVKSLIEK EVLKGDKRTL CGILDTAVFD
LNKKVVNNDY EDYVHRVGDF DERIFSSPDA LTEIGTPVKA TFNSIASFEE QKLMVYPARR
NLQSQFDGSH HLALATPLTG RNFLKAKEPG SVTPVSTATQ SVSRLQALVS GRQTGPSEEL
RRIFSECSNN PGESIQARVK EMGEKFCAHY VNQADEGRTN GFSMDMARKR LQLGESLYYK
VLEKIIIDER RRLKAGTDLS GILQQDMLHQ LLITCCLEIV LFSYNSQRTF PWILEVFPIQ
PFYFYKVIEV LIRAEDLSRD VVKHLNHMEE QILESMAWRY QSPLWEYLKS CDQPIPSCEE
VSLPSQLLPP TPSAPQTPAV VQSSDPVRNT PQQPIPYSPS TYVTNKRAES SLAASLLQSP
VSSVASVNER TPAQSSRRKL FPGPETVPPS PSNTAATPAS VGNAIKASSK LELNDQKMEL
LPSPSVVTTA DNKPKRTGSL SLFFRKFYHL ASVRLQDLCN RLELYEEDLR KKIWTCFEFS
VMKHSDLMQD RHLDQILMCA VYVICKVTGR DKNFTDIMRC YRTQPHASSH VYRSVLLCTK
ARRGSASEED DEAATGSTVK VNGDEKKAET NGEKALPPVR SSSTLPFPQP SSCPPTPTGL
AGTSSSFEYE DRGDLILFYN TVYVRRLQAF ALKFSNRNRL VESLPLSPLP LQRHVPLSPR
RKVSAKHTVF ISPLKGNVIS HSPLPMRYSF NRSPSKDLQA INAFLREERP TKRLLSYEIG
PRDAADAAMA PPPPKFAMTV ENAGAARKIS FH
//