ID E9GVP7_DAPPU Unreviewed; 376 AA.
AC E9GVP7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN ORFNames=DAPPUDRAFT_306142 {ECO:0000313|EMBL:EFX76488.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX76488.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX76488.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR EMBL; GL732568; EFX76488.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GVP7; -.
DR STRING; 6669.E9GVP7; -.
DR EnsemblMetazoa; EFX76488; EFX76488; DAPPUDRAFT_306142.
DR KEGG; dpx:DAPPUDRAFT_306142; -.
DR eggNOG; ENOG502QT7T; Eukaryota.
DR HOGENOM; CLU_042971_1_0_1; -.
DR InParanoid; E9GVP7; -.
DR OMA; AAHSCQL; -.
DR PhylomeDB; E9GVP7; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0019202; F:amino acid kinase activity; IBA:GO_Central.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 70..276
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 376 AA; 42755 MW; 09C173DA47DEB644 CRC64;
MEKEGEILLK PGQQIKPHVP NEVVHQLVFK LYNLEVASVK ELNSYDDKNF HVTVESDSAL
PDIHDACPHG YVLKVLNSLD SKAYNLIDAQ NEMMLYLAKT GLPCPRPVKN VDGKSMSLEH
LKDAQNQSTD QYIVRLLSFV PGKILFSVPY TKELFFQVGE LVAKTDLALM GFKHNGLKGV
DRIWSLIAVP KLVDFVYVIA DEQKHSISME VIENFKSNVI PFLQELESGP IHGDFNEQNI
LVEADKEDPE KYSISGMLDF GDVHFGYYLF DIAIAICYMM IECKSMDMLD APGHVLAGYN
RVRPIPQKEF DLLKDCISAR FSQSLVLGAY SYSQNPDPYL LTTAQRGWQC LKTLWDCPKG
ELYKRWNEII NSYDNN
//
