ID E9H1Y3_DAPPU Unreviewed; 526 AA.
AC E9H1Y3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Cytosol aminopeptidase domain-containing protein {ECO:0000259|PROSITE:PS00631};
GN ORFNames=DAPPUDRAFT_307351 {ECO:0000313|EMBL:EFX74288.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX74288.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX74288.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; GL732584; EFX74288.1; -; Genomic_DNA.
DR AlphaFoldDB; E9H1Y3; -.
DR STRING; 6669.E9H1Y3; -.
DR MEROPS; M17.006; -.
DR EnsemblMetazoa; EFX74288; EFX74288; DAPPUDRAFT_307351.
DR KEGG; dpx:DAPPUDRAFT_307351; -.
DR eggNOG; KOG2597; Eukaryota.
DR HOGENOM; CLU_013734_3_1_1; -.
DR InParanoid; E9H1Y3; -.
DR OMA; MVCEQSD; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR Gene3D; 3.40.50.10590; Zn-dependent exopeptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR041417; NPEPL1_N.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF18295; Pdase_M17_N2; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 345..352
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 526 AA; 56144 MW; 3B95138F2B0114AA CRC64;
MAGVKFKFSS ILSPSDPITN PVVIIGTPKN LAKISYNDMS TKFGGRVTED VFSSALNSVQ
SSPDVCPLYL NSATISPLPG KCSRHNAPSR SHAITKCVRS AATSGKDNFI VIICGKQDVF
PSATAVARAY PLYSRKTNLS SKLGATSAEK VPITVSVEYF LLDNAIPLTE DECEMLEIAA
ESVRLSARIV DTPCNEMNTD HFLEEIGIVA KELGIEPFII RDKELERQGF GGIYGVGKAA
PNPPALVVLS HLPKGATKTI AWVGKGIMYD TGGLSIKGKT AMPGMKRDCG GASGILGAFR
LAVLTGFKEN LHAVFCLAEN SVGPLSTRPD DIHTLYSGRT VEINNTDAEG RLVLADGVFY
AHKDLKADVI LDMATLTGGQ SVATGKQHAA VLTNNEHWEN ALVDAGLVSG DLTFPIPFCP
EFHFSEFNSA VADMKNSVAD RSNALSSCAG LFILAHLGFD YPGVWMHVDM AAPVHCGERA
TGYGVALLVS LFGQYSSSAL LQNIGPVLEE SADDGNENER KKKRLN
//
