ID E9H8K6_DAPPU Unreviewed; 1179 AA.
AC E9H8K6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFX71927.1};
DE Flags: Fragment;
GN ORFNames=DAPPUDRAFT_10143 {ECO:0000313|EMBL:EFX71927.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX71927.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX71927.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732605; EFX71927.1; -; Genomic_DNA.
DR AlphaFoldDB; E9H8K6; -.
DR STRING; 6669.E9H8K6; -.
DR EnsemblMetazoa; EFX71927; EFX71927; DAPPUDRAFT_10143.
DR EnsemblMetazoa; XM_046596364.1; XP_046452320.1; LOC124200205.
DR KEGG; dpx:DAPPUDRAFT_10143; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_003405_0_1_1; -.
DR InParanoid; E9H8K6; -.
DR OMA; DHIPKVC; -.
DR PhylomeDB; E9H8K6; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF355; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 4..105
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 212..398
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 443..572
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 619..745
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 947..1179
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 765..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFX71927.1"
FT NON_TER 1179
FT /evidence="ECO:0000313|EMBL:EFX71927.1"
SQ SEQUENCE 1179 AA; 132426 MW; 737EF5296831FFEE CRC64;
ARYDATIAGA LYKRTSDGSK WQLRWFTLYQ NVLFYWEAES SSRPSGVIFL EGSYCDRVIS
VSAAGHQQYC FAITFRRDNQ RSYELRAESE SDCKAWIQAV KQASFNKLLA QKEELEQKHL
HLLQIVESEK TAKWQYTRQC EELTDEIKQL RTEVGADGGS QSGMGSAGNV ELDDLKKIRK
VQGFFRGWLC RHRWKVIVEE YIKSPHAESM RKRNSLVFRM LEDEEENVQQ LEILVARFYR
PFKMAASSKK PPCSHEDISS IFLNSETILF LHQIFYKGLQ ARMNNWPTLV LGDLFDVLLP
MLNIYQEYVR NHHFSLQILT ECKQNPQFSS VLSRLEEHSA CKGRSLETFL TYPMHQIPRY
IITLHEILAH TPHEHVERRS LENARVQLEH LSRQMHDEVS ETENIRKCLA IERMIVEGCD
ILMDVTQVFV RQGSLLHIVK EKARSQKGRL SLSSRRGSVG TGVGGERGEV RQCFLFSNTL
IIATRTSDGK LHLLPEIGKI PFVDATLIED PTETSSCDDD DGIHSGTNYH GLDFQLIVEN
KSGNGPGKVV HLVAPSMQDK AAWISDISQC IDNVHFNDFV HSSISDASSV THPHSVRNDP
RLFNDDIDIR FSRTLNSCKV PQIRYATPER LLERLTDLRF LSIDFLNTFL LTYRVFTDGV
TVLDALKKVF YASSTVEPAQ HDNALQLNSE ACLANWIRAS SIRRTRVFSD RPPGVLAAEA
PSQPVRATAR SPARAEAING VAVLPLATSP TSSAAAAFAV ATAGSSNPRD YSLPTGPSRT
GPGSILGGGS VGAGGTRSQT YCSINLPSSD PRGSFGGAVQ QQPSSSESGT GGGSGPGTGG
QVFRDRKESI MSSAATMRVL SVLRHWISKH RDDFESSTSG DLRLKNLTIE FLEDVLSSPQ
LLPAEHKAAS QLLQLLTRDD PSHTKIDLGI LLAQPVIQSR ENIETLSALE IAEQMTVLDH
AILASIKSEE LLGQAWMKPD KLFRAPHIIL ITKRFNEVSR LVASEVIRRP NLAARIAVIE
KWTAVADICR CLHNFNGVLQ ICSAFTNSGV FRLKKTWEKL SKTTRQTIDK LQSIVSTDGR
FRNLRDALHR CDPPCIPYLG MYLTDLSFIE EGTPDFTEDG LLNFSKMRMV AHVIREIRHF
QSTSYKIEHS SKVNSYLLDV NNLVDDEDLY QMSLEIEPR
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