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Database: UniProt
Entry: E9HY70_DAPPU
LinkDB: E9HY70_DAPPU
Original site: E9HY70_DAPPU 
ID   E9HY70_DAPPU            Unreviewed;       474 AA.
AC   E9HY70;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=DAPPUDRAFT_119325 {ECO:0000313|EMBL:EFX63311.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX63311.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K.,
RA   Bauer D.J., Caceres C.E., Carmel L., Casola C., Choi J.H.,
RA   Detter J.C., Dong Q., Dusheyko S., Eads B.D., Frohlich T.,
RA   Geiler-Samerotte K.A., Gerlach D., Hatcher P., Jogdeo S.,
RA   Krijgsveld J., Kriventseva E.V., Kultz D., Laforsch C., Lindquist E.,
RA   Lopez J., Manak J.R., Muller J., Pangilinan J., Patwardhan R.P.,
RA   Pitluck S., Pritham E.J., Rechtsteiner A., Rho M., Rogozin I.B.,
RA   Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D.,
RA   Tu H., Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y.,
RA   Shaw J.R., Andrews J., Crease T.J., Tang H., Lucas S.M.,
RA   Robertson H.M., Bork P., Koonin E.V., Zdobnov E.M., Grigoriev I.V.,
RA   Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL733117; EFX63311.1; -; Genomic_DNA.
DR   STRING; 6669.DappuP119325; -.
DR   EnsemblMetazoa; EFX63311; EFX63311; DAPPUDRAFT_119325.
DR   KEGG; dpx:DAPPUDRAFT_119325; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; E9HY70; -.
DR   KO; K02154; -.
DR   PhylomeDB; E9HY70; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000305};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    138    157       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    228    246       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    295    314       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    436    460       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   474 AA;  54057 MW;  11C3C96308B8D08E CRC64;
     MPEYCFIQGC PNHYRGKKTL GATTNVTDPT KSRLFRVPKD DILKKIWSEK IPRTVITRES
     LMETESMTRA LIPEDVTSRQ VVSPQNLGFV AGVILRERLF DDAGHGLLMT LFALWMVVKE
     KPLAAKKIQS EIWVICFAGR YIMLLMGLFS IYAGFIYNDV FSKGVNIFGS AYKVNLTDHE
     LQHHHSGMLV PNEANNHYRQ TPYPFGVDPI WMLAENKIPY LNAYKMKISI IFGVVHMGFG
     VILGIWNHRG SYPWMCTFDS HHLYWHGTVQ VRDDTVALDG CENYMYPGQE TLQKVMIITA
     VLVVPILLFG KPILFKMEMN KAKNHAVNYF LSDYLDVFSK LPIFIQTLHN HNGTAEGEDV
     EVAGVPQTEN HEGGDEPHEF SDVMIHQAIH TIEYVLGSVS HTASYLRLWA LSLAHSQLSE
     VLWLMVLRKG LMFQDWYGGV ILYFIFAAWA ALTVSILVLM EGLSAFLHTL RLHW
//
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