ID E9I0R0_DAPPU Unreviewed; 633 AA.
AC E9I0R0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=DAPPUDRAFT_336969 {ECO:0000313|EMBL:EFX62417.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX62417.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX62417.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GL733605; EFX62417.1; -; Genomic_DNA.
DR AlphaFoldDB; E9I0R0; -.
DR STRING; 6669.E9I0R0; -.
DR EnsemblMetazoa; EFX62417; EFX62417; DAPPUDRAFT_336969.
DR KEGG; dpx:DAPPUDRAFT_336969; -.
DR HOGENOM; CLU_002472_10_2_1; -.
DR InParanoid; E9I0R0; -.
DR OMA; ISPARIM; -.
DR PhylomeDB; E9I0R0; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 489..505
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 633 AA; 70960 MW; 8D7AE004768191B2 CRC64;
MDKLKDIPPV IHCCIAMAHE HLKQFKLEQM VKMINDVKPY EAFDDNVLQM DGNCVRNLNL
VPLTNETGPQ LIGSVYHVLN QTRTKPGARL LRSWLLRPLA CRDLIESRLE AVGFFVDHFE
DPELAPFKKF LKSLPDLEKQ LTAVLHSRSK PKEFHGLCKS WEQLTILCVE LQSHYKNVLP
LSVALLINSA VDSLKMAPFY AEQLSDVAIS SGEKTKLFNR LEDYPEMKML FEKIQQTESK
IQALKPSICK SIGLLALNYV TVSGDEYLIE VKNALIRAVP SSWIKISATK QCCRYRSPEV
QQLFGELCCL RELLKISADE AWLQFQRQVS TTSYSTFRRA NNAIATLDCL IALSDVAKSE
NYVRPTFVDE AGVLNVSQGR HPVLSRILQQ TSSAEYIPND TKLNTDGVRC MIITGPNMGG
KSCLLSQVGI LVVLAQIGSF VPAVEASLSV FKSIFIRMGL HDEIYAGRST FFIEMMETSA
ILKSCTSRSL VIIDELGRGT GTHDGSAIAY AALKYLVKQT KCITLFVTHY PVIVQLEDEF
PGHVANYHMG YILESEKADN VQADCDEEAL VFLYTLTPGN SPKSFGLNVA RLAGIPSSIT
DRAKLKSESF FTEAESQRTK IAEFKRIFYK NHD
//
