ID E9IMH5_SOLIN Unreviewed; 342 AA.
AC E9IMH5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE Flags: Fragment;
GN ORFNames=SINV_80064 {ECO:0000313|EMBL:EFZ18228.1};
OS Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Solenopsis.
OX NCBI_TaxID=13686;
RN [1] {ECO:0000313|EMBL:EFZ18228.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21282665; DOI=10.1073/pnas.1009690108;
RA Wurm Y., Wang J., Riba-Grognuz O., Corona M., Nygaard S., Hunt B.G.,
RA Ingram K.K., Falquet L., Nipitwattanaphon M., Gotzek D., Dijkstra M.B.,
RA Oettler J., Comtesse F., Shih C.J., Wu W.J., Yang C.C., Thomas J.,
RA Beaudoing E., Pradervand S., Flegel V., Cook E.D., Fabbretti R.,
RA Stockinger H., Long L., Farmerie W.G., Oakey J., Boomsma J.J., Pamilo P.,
RA Yi S.V., Heinze J., Goodisman M.A., Farinelli L., Harshman K., Hulo N.,
RA Cerutti L., Xenarios I., Shoemaker D., Keller L.;
RT "The genome of the fire ant Solenopsis invicta.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:5679-5684(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; GL764148; EFZ18228.1; -; Genomic_DNA.
DR AlphaFoldDB; E9IMH5; -.
DR EnsemblMetazoa; XM_039448291.1; XP_039304225.1; LOC105194006.
DR HOGENOM; CLU_002173_6_0_1; -.
DR OMA; RTHGHAC; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254:SF429; E3 UBIQUITIN-PROTEIN LIGASE SU(DX); 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 9..42
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 52..85
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 146..316
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 342
FT /evidence="ECO:0000313|EMBL:EFZ18228.1"
SQ SEQUENCE 342 AA; 40506 MW; 675A96EED695AA8F CRC64;
MIDDDDALGP LPAGWEKRKQ PEGRVYYVNH KNRTTQWEDP RTQGQETGMD EPPLPDGWEI
RLTEDGVRYF VDHNTRTTTF QDPRPGAPKG PKGVYRVPRA YERSFRWKLS QFRFLCQTNA
LPNHIKISVS RQTLFEDSYH QIMNAEAFAL RRRLYIIFKG EEGLDYGGVS REWFFLLSHE
VLNPMYCLFE YANKSNYSLQ INPASYVNPD HLQYFKFIGR FIAMALYHGR FIYSGFTMPF
YKRMLNKKLV MKDIESIDPE FYKSLVWIKE NNIDECGLEL YYSVDFEILG QVIHHELKEG
GDKVRVGEDN KEEYIREHSN FENIFIFEML TIEMRLCSLK QT
//
