ID E9JZW5_ANOGA Unreviewed; 206 AA.
AC E9JZW5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Calpain {ECO:0000313|EMBL:ADD50469.1};
DE Flags: Fragment;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:ADD50469.1};
RN [1] {ECO:0000313|EMBL:ADD50469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BF3863 {ECO:0000313|EMBL:ADD50490.1}, BF4026
RC {ECO:0000313|EMBL:ADD50496.1}, BF4028 {ECO:0000313|EMBL:ADD50497.1},
RC BF6318 {ECO:0000313|EMBL:ADD50501.1}, BF6359
RC {ECO:0000313|EMBL:ADD50502.1}, BF6727 {ECO:0000313|EMBL:ADD50503.1},
RC BF6790 {ECO:0000313|EMBL:ADD50504.1}, BF7137
RC {ECO:0000313|EMBL:ADD50505.1}, BF7190 {ECO:0000313|EMBL:ADD50506.1},
RC G11 {ECO:0000313|EMBL:ADD50508.1}, G13 {ECO:0000313|EMBL:ADD50510.1},
RC G14 {ECO:0000313|EMBL:ADD50511.1}, G15 {ECO:0000313|EMBL:ADD50512.1},
RC G16 {ECO:0000313|EMBL:ADD50513.1}, G17 {ECO:0000313|EMBL:ADD50514.1},
RC G18 {ECO:0000313|EMBL:ADD50515.1}, G19 {ECO:0000313|EMBL:ADD50516.1},
RC G20 {ECO:0000313|EMBL:ADD50518.1}, KL124
RC {ECO:0000313|EMBL:ADD50469.1}, KL126 {ECO:0000313|EMBL:ADD50470.1},
RC KL188 {ECO:0000313|EMBL:ADD50473.1}, KL191
RC {ECO:0000313|EMBL:ADD50474.1}, KL235 {ECO:0000313|EMBL:ADD50477.1},
RC KL27 {ECO:0000313|EMBL:ADD50478.1}, KL309
RC {ECO:0000313|EMBL:ADD50479.1}, KL57 {ECO:0000313|EMBL:ADD50482.1}, T02
RC {ECO:0000313|EMBL:ADD50535.1}, T103 {ECO:0000313|EMBL:ADD50536.1},
RC T110 {ECO:0000313|EMBL:ADD50537.1}, T116
RC {ECO:0000313|EMBL:ADD50538.1}, T281 {ECO:0000313|EMBL:ADD50540.1},
RC T3595 {ECO:0000313|EMBL:ADD50542.1}, T3596
RC {ECO:0000313|EMBL:ADD50543.1}, T3605 {ECO:0000313|EMBL:ADD50545.1},
RC T3608 {ECO:0000313|EMBL:ADD50546.1}, T3619
RC {ECO:0000313|EMBL:ADD50547.1}, T3630 {ECO:0000313|EMBL:ADD50548.1},
RC T3633 {ECO:0000313|EMBL:ADD50549.1}, T55
RC {ECO:0000313|EMBL:ADD50551.1}, T56 {ECO:0000313|EMBL:ADD50552.1}, T57
RC {ECO:0000313|EMBL:ADD50553.1}, and T78 {ECO:0000313|EMBL:ADD50554.1};
RX PubMed=21173248; DOI=10.1073/pnas.1013648108;
RA White B.J., Lawniczak M.K., Cheng C., Coulibaly M.B., Wilson M.D.,
RA Sagnon N., Costantini C., Simard F., Christophides G.K., Besansky N.J.;
RT "Adaptive divergence between incipient species of Anopheles gambiae
RT increases resistance to Plasmodium.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:244-249(2011).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; GU394489; ADD50469.1; -; Genomic_DNA.
DR EMBL; GU394490; ADD50470.1; -; Genomic_DNA.
DR EMBL; GU394493; ADD50473.1; -; Genomic_DNA.
DR EMBL; GU394494; ADD50474.1; -; Genomic_DNA.
DR EMBL; GU394497; ADD50477.1; -; Genomic_DNA.
DR EMBL; GU394498; ADD50478.1; -; Genomic_DNA.
DR EMBL; GU394499; ADD50479.1; -; Genomic_DNA.
DR EMBL; GU394502; ADD50482.1; -; Genomic_DNA.
DR EMBL; GU394510; ADD50490.1; -; Genomic_DNA.
DR EMBL; GU394516; ADD50496.1; -; Genomic_DNA.
DR EMBL; GU394517; ADD50497.1; -; Genomic_DNA.
DR EMBL; GU394521; ADD50501.1; -; Genomic_DNA.
DR EMBL; GU394522; ADD50502.1; -; Genomic_DNA.
DR EMBL; GU394523; ADD50503.1; -; Genomic_DNA.
DR EMBL; GU394524; ADD50504.1; -; Genomic_DNA.
DR EMBL; GU394525; ADD50505.1; -; Genomic_DNA.
DR EMBL; GU394526; ADD50506.1; -; Genomic_DNA.
DR EMBL; GU394528; ADD50508.1; -; Genomic_DNA.
DR EMBL; GU394530; ADD50510.1; -; Genomic_DNA.
DR EMBL; GU394531; ADD50511.1; -; Genomic_DNA.
DR EMBL; GU394532; ADD50512.1; -; Genomic_DNA.
DR EMBL; GU394533; ADD50513.1; -; Genomic_DNA.
DR EMBL; GU394534; ADD50514.1; -; Genomic_DNA.
DR EMBL; GU394535; ADD50515.1; -; Genomic_DNA.
DR EMBL; GU394536; ADD50516.1; -; Genomic_DNA.
DR EMBL; GU394538; ADD50518.1; -; Genomic_DNA.
DR EMBL; GU394555; ADD50535.1; -; Genomic_DNA.
DR EMBL; GU394556; ADD50536.1; -; Genomic_DNA.
DR EMBL; GU394557; ADD50537.1; -; Genomic_DNA.
DR EMBL; GU394558; ADD50538.1; -; Genomic_DNA.
DR EMBL; GU394560; ADD50540.1; -; Genomic_DNA.
DR EMBL; GU394562; ADD50542.1; -; Genomic_DNA.
DR EMBL; GU394563; ADD50543.1; -; Genomic_DNA.
DR EMBL; GU394565; ADD50545.1; -; Genomic_DNA.
DR EMBL; GU394566; ADD50546.1; -; Genomic_DNA.
DR EMBL; GU394567; ADD50547.1; -; Genomic_DNA.
DR EMBL; GU394568; ADD50548.1; -; Genomic_DNA.
DR EMBL; GU394569; ADD50549.1; -; Genomic_DNA.
DR EMBL; GU394571; ADD50551.1; -; Genomic_DNA.
DR EMBL; GU394572; ADD50552.1; -; Genomic_DNA.
DR EMBL; GU394573; ADD50553.1; -; Genomic_DNA.
DR EMBL; GU394574; ADD50554.1; -; Genomic_DNA.
DR AlphaFoldDB; E9JZW5; -.
DR MEROPS; C02.028; -.
DR VEuPathDB; VectorBase:AGAP010834; -.
DR InParanoid; E9JZW5; -.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 1..72
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADD50469.1"
FT NON_TER 206
FT /evidence="ECO:0000313|EMBL:ADD50469.1"
SQ SEQUENCE 206 AA; 24205 MW; 7197DE56C7A72B3F CRC64;
DGVKLLQLKN PWSHLRWRGN YSELDVVHWT PELQRTLGYD PKLAATYDNG VFWIDYRSIM
NFFDVFYLNW DPALFQYTYC IHQAWSAGIG PTKDAYNVGD NPQFSLTVPA GRGSVWILLT
RHITSIEDFR ENHEYITVLV YNSNGRRVYY PTDPPPYIDG VRINSPHYLC KIRLDPGAER
RYTLVVSQYE KTATIYYSLR AYSRTR
//
