ID E9KRX0_SIV Unreviewed; 830 AA.
AC E9KRX0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 08-NOV-2023, entry version 57.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADV74140.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:ADV74140.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ADV74140.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PBE_MO16_42 {ECO:0000313|EMBL:ADV74140.1};
RX PubMed=20357097; DOI=10.1128/JVI.02741-09;
RA Yeh W.W., Rahman I., Hraber P., Coffey R.T., Nevidomskyte D., Giri A.,
RA Asmal M., Miljkovic S., Daniels M., Whitney J.B., Keele B.F., Hahn B.H.,
RA Korber B.T., Shaw G.M., Seaman M.S., Letvin N.L.;
RT "Autologous neutralizing antibodies to the transmitted/founder viruses
RT emerge late after simian immunodeficiency virus SIVmac251 infection of
RT rhesus monkeys.";
RL J. Virol. 84:6018-6032(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HM045225; ADV74140.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADV74140.1};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..520
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 538..731
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT COILED 632..659
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 830
FT /evidence="ECO:0000313|EMBL:ADV74140.1"
SQ SEQUENCE 830 AA; 95330 MW; 9B651C84D651676F CRC64;
MGCLGNQLLI AILLLSVYGI YCIQYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD
NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDK
WGLTKSSIAT AAPTTSNTTP TKSIDVVNET SSCIVHDNCT GLEQEQMIGC KFNMTGLKRD
KKKEYNETWY STDLVCEQGN STDNESRCYM KHCNTSVIQE SCDKHYWDTI RFRYCAPPGY
ALLRCNDTNY SGFMPKCSKV VVSSCTRMME TQTSTWFGFN GTRAENRTYI YWHGRDNRTI
ISLNKYYNLT MKCRRPGNKT VLPVTIMSGL VFHSQPINER PNQAWCRFGG NWKDAIKEVK
QTIVKHPRYT GTNNTDKINL TAPRGGDPEV TFMWTNCRGE FLYCKMNWFL NWVEDRNVTT
QRNYVPCHIR QIINTWHKVG KNVYLPPREG DLTCNSTVTS LIANIDWTDG NQTNITMSAE
VAELYRLELG DYKLVEITPI GLAPTDVKRY ATGGTSRNKR GVFVLGFLGF LATAGTAMGA
ASLTLTAQSR TLLAGIVQQQ QQLLDVVKRQ QELLRLTVWG TKNLQTRVTA IEKYLKDQAQ
LNAWGCAFRQ VCHTTVPWPN ASLTPDWNND TWQEWERKVD FLEENITALL EEAQIQQEKN
MYELQKLNSW DVFGNWFDLA SWIKYIQYGV YVVVGVILLR IVIYIVQMLA RLRQGYRPVF
SSPPSYFQQT YTQQDPALPT REGKEGDGGE GGGNSSWPWQ IEYIHFLIRQ LIRLLTWLFS
NCRTLLSRAY QILQPILQRL SATLRRIREV LRTELTYLQY GWSYFHEAVQ
//