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Database: UniProt
Entry: E9KRX0_SIV
LinkDB: E9KRX0_SIV
Original site: E9KRX0_SIV 
ID   E9KRX0_SIV              Unreviewed;       830 AA.
AC   E9KRX0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   08-NOV-2023, entry version 57.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE   AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:ADV74140.1};
OS   Simian immunodeficiency virus (SIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11723 {ECO:0000313|EMBL:ADV74140.1};
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:ADV74140.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PBE_MO16_42 {ECO:0000313|EMBL:ADV74140.1};
RX   PubMed=20357097; DOI=10.1128/JVI.02741-09;
RA   Yeh W.W., Rahman I., Hraber P., Coffey R.T., Nevidomskyte D., Giri A.,
RA   Asmal M., Miljkovic S., Daniels M., Whitney J.B., Keele B.F., Hahn B.H.,
RA   Korber B.T., Shaw G.M., Seaman M.S., Letvin N.L.;
RT   "Autologous neutralizing antibodies to the transmitted/founder viruses
RT   emerge late after simian immunodeficiency virus SIVmac251 infection of
RT   rhesus monkeys.";
RL   J. Virol. 84:6018-6032(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; HM045225; ADV74140.1; -; Genomic_RNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:ADV74140.1};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   TRANSMEM        6..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        522..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        685..706
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..520
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          538..731
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   COILED          632..659
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         830
FT                   /evidence="ECO:0000313|EMBL:ADV74140.1"
SQ   SEQUENCE   830 AA;  95330 MW;  9B651C84D651676F CRC64;
     MGCLGNQLLI AILLLSVYGI YCIQYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD
     NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDK
     WGLTKSSIAT AAPTTSNTTP TKSIDVVNET SSCIVHDNCT GLEQEQMIGC KFNMTGLKRD
     KKKEYNETWY STDLVCEQGN STDNESRCYM KHCNTSVIQE SCDKHYWDTI RFRYCAPPGY
     ALLRCNDTNY SGFMPKCSKV VVSSCTRMME TQTSTWFGFN GTRAENRTYI YWHGRDNRTI
     ISLNKYYNLT MKCRRPGNKT VLPVTIMSGL VFHSQPINER PNQAWCRFGG NWKDAIKEVK
     QTIVKHPRYT GTNNTDKINL TAPRGGDPEV TFMWTNCRGE FLYCKMNWFL NWVEDRNVTT
     QRNYVPCHIR QIINTWHKVG KNVYLPPREG DLTCNSTVTS LIANIDWTDG NQTNITMSAE
     VAELYRLELG DYKLVEITPI GLAPTDVKRY ATGGTSRNKR GVFVLGFLGF LATAGTAMGA
     ASLTLTAQSR TLLAGIVQQQ QQLLDVVKRQ QELLRLTVWG TKNLQTRVTA IEKYLKDQAQ
     LNAWGCAFRQ VCHTTVPWPN ASLTPDWNND TWQEWERKVD FLEENITALL EEAQIQQEKN
     MYELQKLNSW DVFGNWFDLA SWIKYIQYGV YVVVGVILLR IVIYIVQMLA RLRQGYRPVF
     SSPPSYFQQT YTQQDPALPT REGKEGDGGE GGGNSSWPWQ IEYIHFLIRQ LIRLLTWLFS
     NCRTLLSRAY QILQPILQRL SATLRRIREV LRTELTYLQY GWSYFHEAVQ
//
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