ID E9KY09_HUMAN Unreviewed; 146 AA.
AC E9KY09;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Homeobox protein MSX-1 {ECO:0000256|ARBA:ARBA00039541};
DE AltName: Full=Msh homeobox 1-like protein {ECO:0000256|ARBA:ARBA00042788};
DE Flags: Fragment;
GN Name=MSX1 {ECO:0000313|EMBL:ADR64923.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADR64923.1};
RN [1] {ECO:0000313|EMBL:ADR64923.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21111400; DOI=10.1016/j.archoralbio.2010.10.020;
RA Paixao-Cortes V.R., Braga T., Salzano F.M., Mundstock K., Mundstock C.A.,
RA Bortolini M.C.;
RT "PAX9 and MSX1 transcription factor genes in non-syndromic dental
RT agenesis.";
RL Arch. Oral Biol. 0:0-0(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family.
CC {ECO:0000256|ARBA:ARBA00038425}.
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DR EMBL; HM213990; ADR64923.1; -; Genomic_DNA.
DR AlphaFoldDB; E9KY09; -.
DR ChiTaRS; MSX1; human.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24338; HOMEOBOX PROTEIN MSX; 1.
DR PANTHER; PTHR24338:SF8; HOMEOBOX PROTEIN MSX-1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 13..73
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 15..74
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADR64923.1"
SQ SEQUENCE 146 AA; 15983 MW; A27D01F8D87D92EC CRC64;
RLSPPACTLR KHKTNRKPRT PFTTAQLLAL ERKFRQKQYL SIAERAEFSS SLSLTETQVK
IWFQNRRAKA KRLQEAELEK LKMAAKPMLP PAAFGLSFPL GGPAAVAAAA GASLYGASGP
FQRAALPVAP VGLYTAHVGY SMYHLT
//
