ID   E9M254_CHICK            Unreviewed;       255 AA.
AC   E9M254;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=MHC class II antigen alpha {ECO:0000313|EMBL:ADW77544.1};
GN   Name=B-LA {ECO:0000313|EMBL:ADW77544.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|EMBL:ADW77544.1};
RN   [1] {ECO:0000313|EMBL:ADW77544.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ADW77544.1};
RA   Chen F.;
RT   "Polymorphism and characterization of chicken MHC class II (B).";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HQ172898; ADW77544.1; -; mRNA.
DR   AlphaFoldDB; E9M254; -.
DR   PRO; PR:E9M254; -.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:InterPro.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05767; IgC1_MHC_II_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..255
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003243002"
FT   TRANSMEM        217..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          113..193
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   255 AA;  27975 MW;  BD95B2BE0D49A1AB CRC64;
     MAVLSGAAVP LLLLGVLGGV GAVLKPHVLL QAEFYQRSEG PNKAWAQFGF HFDADELFHV
     ELDAAQTVWR LPEFGRFASF EAQGALQNMA VGKQNLEVMI SNSNRSQQDF VTPELALFPA
     EAVSLEEPNV LICYADKFWP PVATMEWRRN GAVVSEGVYD SVYYGRPDLL FRKFSYLPFV
     PQRGDVYSCA VRHWGAEGPV QRMWEPEVPE PPSESSATLW CAVGLAVGIA GIAAGTALIL
     RAVRRNAANR QPGLL
//