ID E9N922_9HIV1 Unreviewed; 158 AA.
AC E9N922;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADW94332.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADW94332.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADW94332.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HM027 {ECO:0000313|EMBL:ADW94332.1};
RA Ng O., Munshaw S., Laeyendecker O., Lamers S., Chew K., Lin L., Redd A.,
RA Gamaliel J., Quinn T., Ray S., Chua A., Leo Y.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADW94332.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HM027 {ECO:0000313|EMBL:ADW94332.1};
RX PubMed=21235306; DOI=10.1089/aid.2010.0364;
RA Ng O.T., Munshaw S., Lamers S.L., Chew K.K., Lin L., Redd A.D., Manucci J.,
RA Quinn T.C., Ray S.C., Chua A., Leo Y.S., Laeyendecker O.;
RT "Molecular epidemiology of HIV type 1 in Singapore and identification of
RT novel CRF01_AE/B recombinant forms.";
RL AIDS Res. Hum. Retroviruses 27:1135-1137(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ539259; ADW94332.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:ADW94332.1};
KW Virion {ECO:0000313|EMBL:ADW94332.1}.
FT DOMAIN 4..156
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADW94332.1"
FT NON_TER 158
FT /evidence="ECO:0000313|EMBL:ADW94332.1"
SQ SEQUENCE 158 AA; 18585 MW; 217C1C8229FE1E8F CRC64;
GSTMGAASIT LTAQARLLLS GIVQQQNNLL RAIEAQQHML QLTVWGIKQL QARVLAVERY
LRDQQLLGIW GCSGKLICTT AVPWNTSWSN KSLDEIWKNM TWMQWEREID NYTELIYALL
EKSQNQQEKN EQELLELDKW ASLWNWFDIS NWLWYIKI
//
