GenomeNet

Database: UniProt
Entry: E9PCN5_HUMAN
LinkDB: E9PCN5_HUMAN
Original site: E9PCN5_HUMAN 
ID   E9PCN5_HUMAN            Unreviewed;       609 AA.
AC   E9PCN5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 84.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10 {ECO:0000256|ARBA:ARBA00014869, ECO:0000256|RuleBase:RU367083};
GN   Name=CNOT10 {ECO:0000313|Ensembl:ENSP00000402795.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402795.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000402795.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0007829|PubMed:19413330}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [3] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000313|Ensembl:ENSP00000402795.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. {ECO:0000256|RuleBase:RU367083}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367083}.
CC       Nucleus {ECO:0000256|RuleBase:RU367083}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family.
CC       {ECO:0000256|ARBA:ARBA00010080, ECO:0000256|RuleBase:RU367083}.
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DR   EMBL; AC138972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E9PCN5; -.
DR   SMR; E9PCN5; -.
DR   MassIVE; E9PCN5; -.
DR   MaxQB; E9PCN5; -.
DR   PeptideAtlas; E9PCN5; -.
DR   ProteomicsDB; 19478; -.
DR   Ensembl; ENST00000435630.5; ENSP00000402795.1; ENSG00000182973.20.
DR   UCSC; uc062hvi.1; human.
DR   HGNC; HGNC:23817; CNOT10.
DR   VEuPathDB; HostDB:ENSG00000182973; -.
DR   GeneTree; ENSGT00390000001827; -.
DR   ChiTaRS; CNOT10; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000182973; Expressed in right testis and 134 other cell types or tissues.
DR   ExpressionAtlas; E9PCN5; baseline and differential.
DR   GO; GO:0030014; C:CCR4-NOT complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR   PANTHER; PTHR12979:SF5; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367083};
KW   Nucleus {ECO:0000256|RuleBase:RU367083};
KW   Proteomics identification {ECO:0007829|EPD:E9PCN5,
KW   ECO:0007829|MaxQB:E9PCN5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   RNA-mediated gene silencing {ECO:0000256|RuleBase:RU367083};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transcription {ECO:0000256|RuleBase:RU367083};
KW   Transcription regulation {ECO:0000256|RuleBase:RU367083};
KW   Translation regulation {ECO:0000256|RuleBase:RU367083}.
FT   REPEAT          562..595
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..444
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  67091 MW;  F37DA588A7613ADE CRC64;
     MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTV HSAVEEMDGL DDVENSMLYY
     NQAVILYHLR QYTEAISVGE KLYQFIEPFE EKFAQAVCFL LVDLYILTYQ AEKALHLLAV
     LEKMISQGNN NKNGKNETGN NNNKDGSNHK AESGALIEAA KSKIHQYKVR AYIQMKSLKA
     CKREIKSVMN TAGNSAPSLF LKSNFEYLRG NYRKAVKLLN SSNIAEHPGF MKTGECLRCM
     FWNNLGCIHF AMSKHNLGIF YFKKALQEND NVCAQLSAGS TDPGKKFSGR PMCTLLTNKR
     YELLYNCGIQ LLHIGRPLAA FECLIEAVQV YHANPRLWLR LAECCIAANK GTSEQETKGL
     PSKKGIVQSI VGQGYHRKIV LASQSIQNTV YNDGQSSAIP VASMEFAAIC LRNALLLLPE
     EQQDPKQENG AKNSNQLGGN TESSESSETC RCSILACSAY VALALGDNLM ALNHADKLLQ
     QPKLSGSLKF LGHLYAAEAL ISLDRISDAI THLNPENVTD VSLGISSNEQ DQGSDKGENE
     AMESSGKRAP QCYPSSVNSA RTVMLFNLGS AYCLRSEYDK ARKCLHQAQW LMPPSTLGGR
     GRRIMRSGV
//
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