ID E9PCN5_HUMAN Unreviewed; 609 AA.
AC E9PCN5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=CCR4-NOT transcription complex subunit 10 {ECO:0000256|ARBA:ARBA00014869, ECO:0000256|RuleBase:RU367083};
GN Name=CNOT10 {ECO:0000313|Ensembl:ENSP00000402795.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000402795.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000402795.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0007829|PubMed:19413330}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [3] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [5] {ECO:0000313|Ensembl:ENSP00000402795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. {ECO:0000256|RuleBase:RU367083}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367083}.
CC Nucleus {ECO:0000256|RuleBase:RU367083}.
CC -!- SIMILARITY: Belongs to the CNOT10 family.
CC {ECO:0000256|ARBA:ARBA00010080, ECO:0000256|RuleBase:RU367083}.
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DR EMBL; AC138972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E9PCN5; -.
DR SMR; E9PCN5; -.
DR MassIVE; E9PCN5; -.
DR MaxQB; E9PCN5; -.
DR PeptideAtlas; E9PCN5; -.
DR ProteomicsDB; 19478; -.
DR Ensembl; ENST00000435630.5; ENSP00000402795.1; ENSG00000182973.20.
DR UCSC; uc062hvi.1; human.
DR HGNC; HGNC:23817; CNOT10.
DR VEuPathDB; HostDB:ENSG00000182973; -.
DR GeneTree; ENSGT00390000001827; -.
DR ChiTaRS; CNOT10; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000182973; Expressed in right testis and 134 other cell types or tissues.
DR ExpressionAtlas; E9PCN5; baseline and differential.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR039740; CNOT10.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12979; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR PANTHER; PTHR12979:SF5; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|RuleBase:RU367083};
KW Nucleus {ECO:0000256|RuleBase:RU367083};
KW Proteomics identification {ECO:0007829|EPD:E9PCN5,
KW ECO:0007829|MaxQB:E9PCN5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU367083};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transcription {ECO:0000256|RuleBase:RU367083};
KW Transcription regulation {ECO:0000256|RuleBase:RU367083};
KW Translation regulation {ECO:0000256|RuleBase:RU367083}.
FT REPEAT 562..595
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67091 MW; F37DA588A7613ADE CRC64;
MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTV HSAVEEMDGL DDVENSMLYY
NQAVILYHLR QYTEAISVGE KLYQFIEPFE EKFAQAVCFL LVDLYILTYQ AEKALHLLAV
LEKMISQGNN NKNGKNETGN NNNKDGSNHK AESGALIEAA KSKIHQYKVR AYIQMKSLKA
CKREIKSVMN TAGNSAPSLF LKSNFEYLRG NYRKAVKLLN SSNIAEHPGF MKTGECLRCM
FWNNLGCIHF AMSKHNLGIF YFKKALQEND NVCAQLSAGS TDPGKKFSGR PMCTLLTNKR
YELLYNCGIQ LLHIGRPLAA FECLIEAVQV YHANPRLWLR LAECCIAANK GTSEQETKGL
PSKKGIVQSI VGQGYHRKIV LASQSIQNTV YNDGQSSAIP VASMEFAAIC LRNALLLLPE
EQQDPKQENG AKNSNQLGGN TESSESSETC RCSILACSAY VALALGDNLM ALNHADKLLQ
QPKLSGSLKF LGHLYAAEAL ISLDRISDAI THLNPENVTD VSLGISSNEQ DQGSDKGENE
AMESSGKRAP QCYPSSVNSA RTVMLFNLGS AYCLRSEYDK ARKCLHQAQW LMPPSTLGGR
GRRIMRSGV
//