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Database: UniProt
Entry: E9PGK7_HUMAN
LinkDB: E9PGK7_HUMAN
Original site: E9PGK7_HUMAN 
ID   E9PGK7_HUMAN            Unreviewed;      1553 AA.
AC   E9PGK7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   25-OCT-2017, entry version 58.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSP00000381026};
GN   Name=TRPM2 {ECO:0000313|Ensembl:ENSP00000381026};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381026, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381026}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3] {ECO:0000313|Ensembl:ENSP00000381026}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000381026}.
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DR   EMBL; AP001063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PGK7; -.
DR   EPD; E9PGK7; -.
DR   PaxDb; E9PGK7; -.
DR   PeptideAtlas; E9PGK7; -.
DR   PRIDE; E9PGK7; -.
DR   Ensembl; ENST00000397932; ENSP00000381026; ENSG00000142185.
DR   UCSC; uc010gpt.2; human.
DR   EuPathDB; HostDB:ENSG00000142185.16; -.
DR   HGNC; HGNC:12339; TRPM2.
DR   OpenTargets; ENSG00000142185; -.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; KOG4195; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   OMA; GSHTGVM; -.
DR   OrthoDB; EOG091G035A; -.
DR   PhylomeDB; E9PGK7; -.
DR   GenomeRNAi; 7226; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000142185; -.
DR   ExpressionAtlas; E9PGK7; baseline and differential.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:InterPro.
DR   GO; GO:0099604; F:ligand-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0071415; P:cellular response to purine-containing compound; IEA:Ensembl.
DR   GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR   GO; GO:0044849; P:estrous cycle; IEA:Ensembl.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
DR   GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR015797; NUDIX_hydrolase_dom-like.
DR   InterPro; IPR029594; TRPM2.
DR   PANTHER; PTHR13800:SF2; PTHR13800:SF2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E9PGK7,
KW   ECO:0000213|PeptideAtlas:E9PGK7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    752    773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    794    818       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    867    889       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    895    914       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    934    957       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1023   1045       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1404   1548       Nudix hydrolase. {ECO:0000259|PROSITE:
FT                                PS51462}.
SQ   SEQUENCE   1553 AA;  176536 MW;  53EEC227F0ADDCC1 CRC64;
     MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS
     SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ
     EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF
     NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG
     VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP
     LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA
     DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR
     EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK
     PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQKVL
     VEDPERPACA PAAPRLQMHH VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ
     GVSLRSLYKR SSGHVTFTMD PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK
     ELSKEEEDTD SSEEMLALAE EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL
     ALEAKDMKFV SHGGIQAFLT KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD
     VGTPAARARA FFTAPVVVFH LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV
     CEEMRQLFYD PDECGLMKKA ALYFSDFWNK LDVGAILLFV AGLTCRLIPA TLYPGRVILS
     LDFILFCLRL MHIFTISKTL GPKIIIVKRM MKDVFFFLFL LAVWVVSFGV AKQAILIHNE
     RRVDWLFRGA VYHSYLTIFG QIPGYIDGVN FNPEHCSPNG TDPYKPKCPE SDATQQRPAF
     PEWLTVLLLC LYLLFTNILL LNLLIAMFNY TFQQVQEHTD QIWKFQRHDL IEEYHGRPAA
     PPPFILLSHL QLFIKRVVLK TPAKRHKQLK NKLEKNEEAA LLSWEIYLKE NYLQNRQFQQ
     KQRPEQKIED ISNKAGLELW GSRTSSVCKS RQFLHLTVVE SRGSEKAPVT TLACLQGCLG
     KHGRVDAMVD LLDLDPLKRS GSMEQRLASL EEQVAQTAQA LHWIVRTLRA SGFSSEADVP
     TLASQKAAEE PDAEPGGRKK TEEPGDSYHV NARHLLYPNC PVTRFPVPNE KVPWETEFLI
     YDPPFYTAER KDAAAMDPMG DTLEPLSTIQ YNVVDGLRDR RSFHGPYTVQ AGLPLNPMGR
     TGLRGRGSLS CFGPNHTLYP MVTRWRRNED GAICRKSIKK MLEVLVVKLP LSEHWALPGG
     SREPGEMLPR KLKRILRQEH WPSFENLLKC GMEVYKGYMD DPRNTDNAWI ETVAVSVHFQ
     DQNDVELNRL NSNLHACDSG ASIRWQVVDR RIPLYANHKT LLQKAAAEFG AHY
//
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