ID E9PV22_MOUSE Unreviewed; 603 AA.
AC E9PV22;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Leucine rich repeat containing 47 {ECO:0000313|Ensembl:ENSMUSP00000133124.2};
GN Name=Lrrc47 {ECO:0000313|Ensembl:ENSMUSP00000133124.2,
GN ECO:0000313|MGI:MGI:1920196};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133124.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133124.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133124.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000133124.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133124.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; E9PV22; -.
DR SMR; E9PV22; -.
DR SwissPalm; E9PV22; -.
DR jPOST; E9PV22; -.
DR MaxQB; E9PV22; -.
DR ProteomicsDB; 349160; -.
DR Antibodypedia; 1623; 36 antibodies from 13 providers.
DR Ensembl; ENSMUST00000169622.8; ENSMUSP00000133124.2; ENSMUSG00000029028.15.
DR AGR; MGI:1920196; -.
DR MGI; MGI:1920196; Lrrc47.
DR VEuPathDB; HostDB:ENSMUSG00000029028; -.
DR GeneTree; ENSGT00530000063489; -.
DR PhylomeDB; E9PV22; -.
DR TreeFam; TF315742; -.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000029028; Expressed in secondary oocyte and 233 other cell types or tissues.
DR ExpressionAtlas; E9PV22; baseline and differential.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.50.40.10; Phenylalanyl-trna Synthetase, Chain B, domain 3; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR005146; B3/B4_tRNA-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045060; Phe-tRNA-ligase_IIc_bsu.
DR InterPro; IPR020825; Phe-tRNA_synthase-like_B3/B4.
DR PANTHER; PTHR10947:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47; 1.
DR PANTHER; PTHR10947; PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00873; B3_4; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|EPD:E9PV22,
KW ECO:0007829|MaxQB:E9PV22};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 353..529
FT /note="B3/B4 tRNA-binding"
FT /evidence="ECO:0000259|SMART:SM00873"
FT REGION 284..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..454
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 287..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 65904 MW; 3C9BB612C3877F72 CRC64;
MVISGSRRKC GAALRKRRTG GAMAAAAMAV SEAWPELELA ERERRRELLL TGPGLEERVK
AAGGRLPPRL FTLPLLHYLE VSGCGSLRAP GPGLAQGLPQ LHSLVLRRNA LGPGLSPELG
PLPALRVLDL SGNALETLPP GEGLGPAEPP GLPQLQSLNL SGNRLRELPA DLARCAPRLQ
SLNLTGNRLD AFPPELFRPG ALPLLSELAA ADNCLRELSP DIAHLASLKT LDLSNNQLTE
IPAELADCPK LKEINFRGNR LRDKRLEKMV GGCQTKSILE YLRAGGRGGR SKGRQEASEK
EDRKKRRERK QHRESGEGEE EVADSARLML KVLHVSENPT PLTVRVSPEV KDVRPYIVGA
IVRGMDLQPG NALRRFLNSQ TKLHDDLCEK RTAATIATHD LQAVRGPLLY AARPPEDLKI
VPLGRKEAKA KELVRQLQLE AEEQRKQKKR QSVSGLHRYL HLLDGKENYP CLVDAEGDVI
SFPPITNSEK TKIKKTTCNL FLEVTSATSL QLCKDIMDSL ILRMAELSKS TSENKEEDML
SGTEADAGCG LSDPNLTLSS GKDGQCPLVV EQVRVVDLEG SLKVVYPSKT DLITLPPHVT
VVR
//
