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Database: UniProt
Entry: E9PW34_MOUSE
LinkDB: E9PW34_MOUSE
Original site: E9PW34_MOUSE 
ID   E9PW34_MOUSE            Unreviewed;      4888 AA.
AC   E9PW34;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   22-NOV-2017, entry version 61.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMUSP00000089426};
GN   Name=Ryr3 {ECO:0000313|Ensembl:ENSMUSP00000089426,
GN   ECO:0000313|MGI:MGI:99684};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000089426, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000089426, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000089426,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000089426}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000089426};
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000089426}.
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DR   EMBL; AL672250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL732316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX649564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PW34; -.
DR   MaxQB; E9PW34; -.
DR   PaxDb; E9PW34; -.
DR   PRIDE; E9PW34; -.
DR   Ensembl; ENSMUST00000091818; ENSMUSP00000089426; ENSMUSG00000057378.
DR   UCSC; uc008lpg.1; mouse.
DR   MGI; MGI:99684; Ryr3.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   ChiTaRS; Ryr3; mouse.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000057378; -.
DR   ExpressionAtlas; E9PW34; baseline and differential.
DR   Genevisible; E9PW34; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E9PW34,
KW   ECO:0000213|MaxQB:E9PW34};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4201   4225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4429   4449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4497   4516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4628   4646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4689   4710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4769   4792       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      120    175       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      182    227       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      235    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    353       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      363    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      605    816       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1032   1228       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1274   1486       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3937   3972       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4888 AA;  554567 MW;  ABDEE9857A6A3B37 CRC64;
     MLVEATISIF HESIRHLDDH LLHYRPFNFY DPCFPMQEDE VVLQCIANIH KEQRKFCLAA
     EGLGNRLCFL EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH
     RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS
     EGEKVRIGDD LILVSVSSER YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG
     GHVVRLFHGH DECLTIPSTD QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW
     GQAFRLRHLT TGHYLALTED QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG
     MGVPEIKYGD SVCFVQHVAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
     QQEESQAARI IRNTTALFSQ FVSGNNRTTA PVALPTEEVL QTLQDLIAYF QPPEDEMQHE
     DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL
     YKLLAALIRG NRNNCAQFSN NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH
     IKSIISLLDK HGRNHKVLDV LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT
     SIRPNIFLGV AEGSPQYKKW YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW
     GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ
     PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR
     LEPVKEYKRD ADGVRDLLGT TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW
     GMNKIELGWT YGKVRDDNKR QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV
     NPAAEEDLKK VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
     QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD
     PTVEKVSIDK IRFFRVERSY AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA
     FVFEGSRGQR WHQGSGYFGR TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD
     YEIENGFVPI CSLGLSQIGR MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR
     LPTFVNVPKD HPHIEVVRID GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF
     SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD
     LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG
     MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK
     NPTPQCPPRL DVQTIQPVLW SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN
     RCVDILELCE QEDLMQFHYH TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG
     LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSATRNI RLYPDESKRH GLPGVGLRTC
     LKPGFRFSTP CFVVTSEDHQ KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF
     QFVPVLKLIG TLLVMGVFDD DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA
     GEKACKEAPV KGLLQTRLPE SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ
     KFRYNELMQA LNMSAALTAR KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE
     DLLVHCGVPL EEEEEEEEDT SWTGKLCALV YKIKGPPKPE KEQPTEEEKP YPTTLKELVS
     QTMIRWAQEN QIQDAELVRM MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL
     GQIRSLLSVR MGREEELLMI NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK
     SQIAFPKMVA SCCRFLCYFC RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA
     SSVMDNNELA LGLEEPDLEK VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF
     AVFVNSESVE ENASVVVKLL IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ
     GYKTEVTQDD GEEEEIVHMG NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS
     LVPTEDLVGI ISIPLKLPSL NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL
     HLLEVGFLPD LRASASLDTV SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI
     DSTLQTIYRL SKGRSLTKAQ RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM
     PLKLLTNHYE QCWKYYCLPS GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDLDLFRMA
     LPCLSAIAGA LPPDYLDTRI TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA
     EHSHDKWACD KSHSGWKYGI SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV
     GWTVERTKEG EALVQQRENE KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN
     YHNIWAKKKK LELESKGGGS HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM
     KDLELDASSM EKRFAYKFLK KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV
     LLPLVDQYFT NHRLYFLSSP LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS
     TTMVSCLHIL AQTLDTRTVM KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ
     IKGVSQNINY TTVALLPILT SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI
     YVERQRPALG ECLASLAAAI PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP
     DIPQLEGLMK EINDLAESGA RYTEMPHVIE VILPMLCNYL SYWWERGPEN LPPSTGPCCT
     KVTSEHLSLI LGNILKIINN NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL
     KKKAVKTVQE EEQLKTDGKG DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK
     SPDPDSDQLF RMVAEVFILW CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKAMQVK
     SGGQDQERKK TKRRGDLYSI QTSLIVAALK KMLPIGLNMC TPGDQELISL AKSRYSCRDT
     DEEVKEHLRN NLHLQEKSDD PAVKWQLNLY KDVLRNDEPS NPEKTVERVQ SISAALFHLE
     QVEQPLRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH RSINLFLHGY QRFWIETEAH
     FFEEKLVQDL AKSPRVEDEE EEETERQPDP LHQIILHFSR NALTERSKLE DDPLYTSYSS
     MMAKSCQSGE DEEEEEDKEK TFEEKEMEKQ KTLYQQARLH ERGAAEMVLQ MISASKGEMS
     PMVVETLKLG IAILNGGNAG VQQKMLDYLK EKKDAGFFQS LSGLMQSCSV LDLNAFERQN
     KAEGLGMVTE EGTLIVRERG EKVLQNDEFT QDLFRFLQLL CEGHNSDFQN FLRTQMGNTT
     TVNIIISTVD YLLRLQESIS DFYWYYSGKD IIDESGQHNF SKALAVTKQI FNSLTEYIQG
     PCIGNQQSLA HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL
     EGNVVNGTIG KQMVDTLVES STNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGIISRK
     EFQKAMEGLK QYTQSEIDFL LSCTEADEND MFNYVDFVER FHEPAKDIGF NVAVLLTNLS
     EHMPNDSRLK SLLDPAESVL NYFEPYLGRI EIMGGAKKIE RVYFEISESS RTQWEKPQVK
     ESKRQFIFDV VNEGGEQEKM ELFVNFCEDT IFEMQLASQI SESDSTDRPE EEEEEDEDSA
     YSIETEGEEE EKSFESASAF TMACVSVKRN VTKFLKRATL KNLRKQYRNV KKMSAKELVK
     VFFSFFWMLF VGLFQLLFTI FGGIFQILWN TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG
     IHDDVIETDR AEVTEPGVTT ELVHFVKGEA GDTDIMSDLF GIHSKKEGGL KQGPEVGLGD
     LSEIIGKDEP PTLESTVRKK RKAQAAEMKA VHEAEGKAES EKADMEDREK EDKIKEEGQT
     DYLWADVTVK KTRRRGQKAE KPEAFMANFF KGLEIYQTKL LHYLARNFYN LRFLALFVAF
     AINFILLFYK VTEEPLEEET EDVANLWNSF NDDDEEEAMV FFVLQESTGY MAPTLRALAI
     VHTIISLVCV VGYYCLKVPL VVFKREKEIA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
     PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKNAL DFSPVEEAKA EAASLVSWLS
     SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS
     VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV
     GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
     VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY
     VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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